Epileptogenesis in immature rats following recurrent status epilepticus

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dc.contributor.authorSantos, N. F. dos
dc.contributor.authorArida, R. M.
dc.contributor.authorTrindade, E. M.
dc.contributor.authorPriel, M. R.
dc.contributor.authorCavalheiro, E. A.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:31:03Z
dc.date.available2016-01-24T12:31:03Z
dc.date.issued2000-04-01
dc.description.abstractStrong evidences link; status epilepticus (SE) in childhood with the later development of epilepsy. Pilocarpine-induced SE in developing rats leads to late appearance of spontaneous epileptic seizures only when SE is induced after the 18th day of life. We examined the possibility that 3 consecutive episodes of pilocarpine-induced SE on postnatal days 7, 8 and 9 could induce behavioral, electrographic and histological epileptic changes in adult life. the animals also underwent behavioral tests (inhibitory step-down avoidance, skinner box, rota-rod, open field and elevated plus-maze). EEG recordings made at the age of 30, 60 and 90 days showed the occurrence of several episodes of spikes and/or polyspikes appearing simultaneously in hippocampus and cortex. Only three isolated spontaneous seizures were observed during the whole period of observation (120 days). the long-term effects of three consecutive episodes of SE include increased spontaneous exploratory activity, learning impairment, and reduced anxiety when tested on P60. Our findings provide evidence for EEG changes and cognitive deficits in adult life following recurrent SE on postnatal days 7-9. (C) 2000 Elsevier Science B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent269-276
dc.identifierhttp://dx.doi.org/10.1016/S0165-0173(99)00089-2
dc.identifier.citationBrain Research Reviews. Amsterdam: Elsevier B.V., v. 32, n. 1, p. 269-276, 2000.
dc.identifier.doi10.1016/S0165-0173(99)00089-2
dc.identifier.issn0165-0173
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26281
dc.identifier.wosWOS:000087131200033
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research Reviews
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectimmature brainen
dc.subjectpilocarpineen
dc.subjectlearningen
dc.subjectmemoryen
dc.subjectrepeated status epilepticusen
dc.subjectepileptogenesisen
dc.titleEpileptogenesis in immature rats following recurrent status epilepticusen
dc.typeinfo:eu-repo/semantics/article
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