Metabolic profile and cardiovascular risk patterns of an Indian tribe living in the Amazon Region of Brazil

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dc.contributor.authorTavares, E. F.
dc.contributor.authorVieira, JPB
dc.contributor.authorAndriolo, A.
dc.contributor.authorSanudo, A.
dc.contributor.authorGimeno, SGA
dc.contributor.authorFranco, L. J.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:33:43Z
dc.date.available2016-01-24T12:33:43Z
dc.date.issued2003-02-01
dc.description.abstractThe Parkateje Indians, belonging to the Je group and inhabiting the Mae Maria Reservation in the southeast of the state of Para in the Amazon Region of Brazil, have suffered rapid and intensive cultural changes in recent years. This survey was designed to characterize the metabolic profile and the frequency of cardiovascular risk factors in this community. Ninety subjects (90.0% of the adult population without admixture) were investigated. Anthropometric measurements were performed and the following clinical characteristics measured: glycemia, serum insulin and proinsulin (fasting and 2-hr post 75 g of glucose load), beta-cell function (%B) and insulin sensitivity (%S) estimated by HOMA, HbA1c, GAD65 antibody, serum lipids, uric acid, creatinine, leptin, and blood pressure. Information about alcohol use, smoking, and medical history was obtained through individual interviews. the prevalences were: overweight, 67.8%; obesity, 14.4%; central obesity, 72.2%; hypertension, 4.4%; dyslipidemia, 44.4%; hyperuricemia, 5.6%; GAD65 antibody positivity, 4.4%; smoking, 25.6%; chronic alcohol use, 0.0%. One case of impaired glucose tolerance (1.1%) and one case of impaired fasting glycemia (1.1%) were diagnosed during this study and one case of diabetes (1.1%) was diagnosed previously. the diabetic woman was excluded from the analyses involving HbA1c, glycemia, insulin, proinsulin, %B, and %S. All creatinine values were normal. Blood pressure did not correlate with age, anthropometric measurements, insulin, proinsulin, and natural logarithm (In) transformed %S. After adjustment for age and sex, there were positive correlations between total cholesterol and body mass index (BMI; r = 0.24), triglycerides and BMI (r = 0.44), triglycerides and waist-to-hip ratio (WHR; r = 0.52), in leptin and BMI (r = 0.41), in leptin and WHR (r = 0.29), uric acid and systolic blood pressure (r = 0.34), uric acid and triglycerides (r = 0.22). Systolic (r = 0.04; r = 0.70) and diastolic (r = 0.14; p = 0.18) blood pressure did not correlate with BMI. Ln leptin had a weak positive correlation with 2-hr insulin (r = 0.14) adjusted for age, sex, and BMI. the multiple linear regression model containing the variables sex, BMI, and 2-hr insulin concentrations explained 77.2% of the variation of in leptin. in conclusion, the high rates of cardiovascular risk factors found among these Indians point to there being a high-risk group to develop diabetes and cardiovascular diseases. To reduce this risk they need to receive preventive interventions.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Endocrinol Sect, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Clin Pathol Sect, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Prevent Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Endocrinol Sect, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Clin Pathol Sect, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Prevent Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent31-46
dc.identifierhttp://dx.doi.org/10.1353/hub.2003.0028
dc.identifier.citationHuman Biology. Detroit: Wayne State Univ Press, v. 75, n. 1, p. 31-46, 2003.
dc.identifier.doi10.1353/hub.2003.0028
dc.identifier.issn0018-7143
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27148
dc.identifier.wosWOS:000182269000003
dc.language.isoeng
dc.publisherWayne State Univ Press
dc.relation.ispartofHuman Biology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBrazilian Indiansen
dc.subjectcardiovascular risk factorsen
dc.subjectinsulinen
dc.subjectleptinen
dc.titleMetabolic profile and cardiovascular risk patterns of an Indian tribe living in the Amazon Region of Brazilen
dc.typeinfo:eu-repo/semantics/article
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