Antiretroviral Drug Resistance in a Respondent-Driven Sample of HIV-Infected Men Who Have Sex With Men in Brazil

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dc.contributor.authorBermudez-Aza, Elkin Hernan [UNIFESP]
dc.contributor.authorKerr, Ligia Regina Franco Sansigolo
dc.contributor.authorKendall, Carl
dc.contributor.authorPinho, Adriana Araujo
dc.contributor.authorMello, Maeve Brito de
dc.contributor.authorMota, Rosa Salani
dc.contributor.authorCrosland Guimaraes, Mark Drew
dc.contributor.authorAlencar, Cecilia Salete [UNIFESP]
dc.contributor.authorBrito, Ana Maria de
dc.contributor.authorDourado, Ines Costa
dc.contributor.authorBatista da Batista, Sonia Maria
dc.contributor.authorAbreu, Fabiano
dc.contributor.authorOliveira, Lisangela Cristina de
dc.contributor.authorMoraes, Adao de Souza
dc.contributor.authorBenzaken, Adele Schwartz
dc.contributor.authorMerchan-Hamann, Edgar
dc.contributor.authorFreitas, Gisele Maria Brandao de
dc.contributor.authorMcFarland, Willi
dc.contributor.authorAlbuquerque, Elizabeth
dc.contributor.authorRutherford, George W.
dc.contributor.authorSabino, Ester [UNIFESP]
dc.contributor.institutionUniv Fed Ceara
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionTulane Univ
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.contributor.institutionUniv Calif San Francisco
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:17:05Z
dc.date.available2016-01-24T14:17:05Z
dc.date.issued2011-08-15
dc.description.abstractBackground: There are few studies on HIV subtypes and primary and secondary antiretroviral drug resistance (ADR) in community-recruited samples in Brazil. We analyzed HIV clade diversity and prevalence of mutations associated with ADR in men who have sex with men in all five regions of Brazil.Methods: Using respondent-driven sampling, we recruited 3515 men who have sex with men in nine cities: 299 (9.5%) were HIV-positive; 143 subjects had adequate genotyping and epidemiologic data. Forty-four (30.8%) subjects were antiretroviral therapy-experienced (AE) and 99 (69.2%) antiretroviral therapy-naive (AN). We sequenced the reverse transcriptase and protease regions of the virus and analyzed them for drug resistant mutations using World Health Organization guidelines.Results: the most common subtypes were B (81.8%), C (7.7%), and recombinant forms (6.9%). the overall prevalence of primary ADR resistance was 21.4% (i.e. among the AN) and secondary ADR was 35.8% (i.e. among the AE). the prevalence of resistance to protease inhibitors was 3.9% (AN) and 4.4% (AE); to nucleoside reverse transcriptase inhibitors 15.0% (AN) and 31.0% (AE) and to nonnucleoside reverse transcriptase inhibitors 5.5% (AN) and 13.2% (AE). the most common resistance mutation for nucleoside reverse transcriptase inhibitors was 184V (17 cases) and for nonnucleoside reverse transcriptase inhibitors 103N (16 cases).Conclusions: Our data suggest a high level of both primary and secondary ADR in men who have sex with men in Brazil. Additional studies are needed to identify the correlates and causes of antiretroviral therapy resistance to limit the development of resistance among those in care and the transmission of resistant strains in the wider epidemic.en
dc.description.affiliationUniv Fed Ceara, Dept Saude Comunitaria, BR-60430971 Fortaleza, Ceara, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationTulane Univ, Sch Publ Hlth & Trop Med, New Orleans, LA USA
dc.description.affiliationUniv Fed Minas Gerais, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Bahia, Inst Saude Colet, BR-41170290 Salvador, BA, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Rio de Janeiro, Brazil
dc.description.affiliationUniv Brasilia, BR-70910900 Brasilia, DF, Brazil
dc.description.affiliationUniv Calif San Francisco, San Francisco, CA 94143 USA
dc.description.affiliationUniv São Paulo, LIM 03, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipMinistry of Health/Secretariat of Health Surveillance/Department of STD, AIDS and Viral Hepatitis through Brazilian Government
dc.description.sponsorshipMinistry of Health/Secretariat of Health Surveillance/Department of STD, AIDS and Viral Hepatitis through United Nations Office on Drugs and Crime-UNODC
dc.description.sponsorshipDepartment of STD, AIDS and Viral Hepatitis of the Ministry of Health
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt
dc.description.sponsorshipIDMinistry of Health/Secretariat of Health Surveillance/Department of STD, AIDS and Viral Hepatitis through Brazilian Government: AD/BRA/03/H34
dc.description.sponsorshipIDMinistry of Health/Secretariat of Health Surveillance/Department of STD, AIDS and Viral Hepatitis through United Nations Office on Drugs and Crime-UNODC: AD/BRA/03/H34
dc.description.sponsorshipIDDepartment of STD, AIDS and Viral Hepatitis of the Ministry of Health: CSV 234/07
dc.description.sponsorshipIDFAPESP: 2004/15856-9pt
dc.description.sponsorshipIDCAPES: BEX 3495/06-0pt
dc.format.extentS186-S192
dc.identifierhttps://dx.doi.org/10.1097/QAI.0b013e31821e9c36
dc.identifier.citationJaids-Journal of Acquired Immune Deficiency Syndromes. Philadelphia: Lippincott Williams & Wilkins, v. 57, p. S186-S192, 2011.
dc.identifier.doi10.1097/QAI.0b013e31821e9c36
dc.identifier.issn1525-4135
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/33958
dc.identifier.wosWOS:000293235900010
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJaids-Journal of Acquired Immune Deficiency Syndromes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHIV-1en
dc.subjectMen who have sex with menen
dc.subjectRespondent-driven samplingen
dc.subjectBrazilen
dc.subjectAntiretroviral resistanceen
dc.titleAntiretroviral Drug Resistance in a Respondent-Driven Sample of HIV-Infected Men Who Have Sex With Men in Brazilen
dc.typeinfo:eu-repo/semantics/article
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