Bactericidal activity of cefepime and ceftriaxone tested against Streptococcus pneumoniae

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dc.contributor.authorPottumarthy, Sudha
dc.contributor.authorSader, Helio S.
dc.contributor.authorJones, Ronald N.
dc.contributor.institutionJMI Labs
dc.contributor.institutionHouston Dept Hlth & Human Serv
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionTufts Univ
dc.date.accessioned2016-01-24T12:41:55Z
dc.date.available2016-01-24T12:41:55Z
dc.date.issued2007-03-01
dc.description.abstractThe bactericidal activities of cefepime, and ceftriaxone were assessed by testing a contemporary collection of 50 Streptococcus pneumoniae strains. Minimum inhibitory and bactericidal concentrations (MIC and MBC, respectively) of cefepime and ceftriaxone were determined, and time-kill studies were performed on 14 selected strains (10 penicillin-resistant, 2-intermediate, and 2-susceptible). Cefepime and ceftriaxone showed essentially identical potency (MIC50, 1 mu g/mL and MIC90, 2 mu g/mL, for both compounds) and MBC values (MBC50, 1 mu g/mL for both). MBC/MIC ratios were <= 4 for cefepime and <= 8 for ceftriaxone on 48 (96.0%) strains, and 2 strains (4.0%) displayed MBC/MIC ratios >= 32 (tolerance) to the 2 cephalosporins. Time-kill curves corroborated the MBC/MIC studies. Cefepime and ceftriaxone bactericidal activity (>= 3 log(10) CFU/mL reduction in inoculum) was demonstrable after 24 h of exposure to 8 X MIC for 13 (92.9%) of 14 strains, whereas I strain showed approximately 2 log(10) CFU/mL reduction. in conclusion, our results indicate that cefepime and ceftriaxone exhibit comparable potency and bactericidal activities when tested against contemporary pneumococcal strains with varying penicillin susceptibility patterns. Both parenteral cephems offer alternative therapeutic choices for the treatment of invasive pneumococcal infections. (c) 2007 Elsevier Inc. All rights reserved.en
dc.description.affiliationJMI Labs, Beaver Kreek Ctr 345, N Liberty, IA 52317 USA
dc.description.affiliationHouston Dept Hlth & Human Serv, Houston, TX 77054 USA
dc.description.affiliationUniversidade Federal de São Paulo, BR-04023900 São Paulo, Brazil
dc.description.affiliationTufts Univ, Sch Med, Boston, MA 02111 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent345-349
dc.identifierhttp://dx.doi.org/10.1016/j.diagmicrobio.2006.08.022
dc.identifier.citationDiagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 57, n. 3, p. 345-349, 2007.
dc.identifier.doi10.1016/j.diagmicrobio.2006.08.022
dc.identifier.issn0732-8893
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29546
dc.identifier.wosWOS:000245221300019
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectcefepimeen
dc.subjectceftriaxoneen
dc.subjectStreptococcus pneumoniaeen
dc.subjectbactericidal activityen
dc.subjecttime kill curveen
dc.subjecttoleranceen
dc.titleBactericidal activity of cefepime and ceftriaxone tested against Streptococcus pneumoniaeen
dc.typeinfo:eu-repo/semantics/article
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