Melatonin treatment decreases c-fos expression in a headache model induced by capsaicin

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dc.contributor.authorTanuri, Fabiano da Cunha [UNIFESP]
dc.contributor.authorLima, Eliângela de [UNIFESP]
dc.contributor.authorPeres, Mario Fernando Prieto [UNIFESP]
dc.contributor.authorCabral, Francisco Romero [UNIFESP]
dc.contributor.authorNaffah-Mazzacoratti, Maria da Graca [UNIFESP]
dc.contributor.authorCavalheiro, Esper Abrão [UNIFESP]
dc.contributor.authorCipolla-Neto, Jose
dc.contributor.authorZukerman, Eliova [UNIFESP]
dc.contributor.authorAmado, Débora [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Israelita Albert Einstein
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T13:52:22Z
dc.date.available2016-01-24T13:52:22Z
dc.date.issued2009-04-01
dc.description.abstractThe aim of the present work was to analyze c-fos response within the trigeminal nucleus caudalis (TNC) of pinealectomized rats and animals that received intraperitoneal melatonin, after intracisternal infusion of capsaicin, used to induce intracranial trigeminovascular stimulation. Experimental groups consisted of animals that received vehicle solution (saline-ethanol-Tween 80, 8:1:1, diluted 1:50) only (VEI, n = 5); animals that received capsaicin solution (200 nM) only (CAP, n = 6); animals submitted to pinealectomy (PX, n = 5); sham-operated animals (SH, n = 5); animals submitted to pinealectomy followed by capsaicin stimulation (200 nM) after 15 days (PX + CAP, n = 7); and animals that received capsaicin solution (200 nM) and intraperitoneal melatonin (10 mg/kg) (CAP + MEL, n = 5). Control rats, receiving vehicle in the cisterna magna, showed a small number of c-fos-positive cells in the TNC (layer I/II) as well as the sham-operated and pinealectomized rats, when compared to animals stimulated by capsaicin. On the other hand, pinealectomized rats, which received capsaicin, presented the highest number of c-fos-positive cells. Animals receiving capsaicin and melatonin treatment had similar expression of the vehicle group. Our data provide experimental evidence to support the role of melatonin and pineal gland in the pathophysiology of neurovascular headaches.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Neurol Neurocirurgia, São Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Ciencias Biomed, Dept Fisiol Biofis, BR-05508 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Bioquim, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Neurol Neurocirurgia, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Bioquim, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent105-110
dc.identifierhttp://dx.doi.org/10.1007/s10194-009-0097-3
dc.identifier.citationJournal of Headache and Pain. New York: Springer, v. 10, n. 2, p. 105-110, 2009.
dc.identifier.doi10.1007/s10194-009-0097-3
dc.identifier.fileWOS000264136800006.pdf
dc.identifier.issn1129-2369
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31390
dc.identifier.wosWOS:000264136800006
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Headache and Pain
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectHeadacheen
dc.subjectMigraineen
dc.subjectPinealectomyen
dc.subjectMelatoninen
dc.subjectc-fosen
dc.subjectExperimental modelsen
dc.titleMelatonin treatment decreases c-fos expression in a headache model induced by capsaicinen
dc.typeinfo:eu-repo/semantics/article
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