Resistance training with instability is more effective than resistance training in improving spinal inhibitory mechanisms in Parkinson's disease

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dc.citation.issue1
dc.citation.volume122
dc.contributor.authorSilva-Batista, Carla
dc.contributor.authorTavares Mattos, Eugenia Casella
dc.contributor.authorCorcos, Daniel M.
dc.contributor.authorWilson, Jessica M.
dc.contributor.authorHeckman, Charles J.
dc.contributor.authorKanegusuku, Helcio
dc.contributor.authorPimentel Piemonte, Maria Elisa
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorForjaz, Claudia
dc.contributor.authorRoschel, Hamilton
dc.contributor.authorTricoli, Valmor
dc.contributor.authorUgrinowitsch, Carlos
dc.coverageBethesda
dc.date.accessioned2020-07-31T12:46:54Z
dc.date.available2020-07-31T12:46:54Z
dc.date.issued2017
dc.description.abstractThis study assessed 1) the effects of 12 wk of resistance training (RT) and resistance training with instability (RTI) on presynaptic inhibition (PSI) and disynaptic reciprocal inhibition (DRI) of patients with Parkinson's disease (PD)en
dc.description.abstract2) the effectiveness of RT and RTI in moving PSI and DRI values of patients toward values of age-matched healthy controls (HCen
dc.description.abstractZ-score analysis)en
dc.description.abstractand 3) associations between PSI and DRI changes and clinical outcomes changes previously published. Thirteen patients in RT group, 13 in RTI group, and 11 in a nonexercising control group completed the trial. While RT and RTI groups performed resistance exercises twice a week for 12 wk, only the RTI group used unstable devices. The soleus H reflex was used to evaluate resting PSI and DRI before and after the experimental protocol. The HC (n = 31) was assessed at pretest only. There were significant group X time interactions for PSI (P < 0.0001) and DRI (P < 0.0001). RTI was more effective than RT in increasing the levels of PSI (P = 0.0154) and DRI (P < 0.0001) at posttraining and in moving PSI [confidence interval (CI) 0.1-0.5] and DRI (CI 0.6 -1.1) levels to those observed in HC. There was association between DRI and quality of life changes (r = -0.69, P = 0.008) and a strong trend toward association between PSI and postural instability changes (r = 0.60, P = 0.051) after RTI. RTI increased PSI and DRI levels more than RT, reaching the average values of the HC. Thus RTI may cause plastic changes in PSI and DRI pathways that are associated with some PD clinical outcomes. NEW & NOTEWORTHY Patients with Parkinson's disease (PD) have motor dysfunction. Spinal inhibitory mechanisms are important for modulating both supraspinal motor commands and sensory feedback at the spinal level. Resistance training with instability was more effective than resistance training in increasing the levels of presynaptic inhibition and disynaptic reciprocal inhibition of lower limb at rest of the patients with PD, reaching the average values of the healthy controls.en
dc.description.affiliationUniv Sao Paulo, Sch Phys Educ & Sport, Lab Adaptat Strength Training, Sao Paulo, Brazil
dc.description.affiliationNorthwestern Univ, Dept Phys Therapy & Human Movement Sci, Chicago, IL 60611 USA
dc.description.affiliationRush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL USA
dc.description.affiliationNorthwestern Univ, Dept Physiol, Chicago, IL 60611 USA
dc.description.affiliationUniv Sao Paulo, Sch Phys Educ & Sport, Exercise Hemodynam Lab, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med Sci, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Ctr Psychobiol & Exercise Studies, Dept Psychobiol, Sao Paulo, Brazil
dc.description.affiliationUnifespDepartment of Psychobiology, Center for Psychobiology and Exercise Studies, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 2011/042423
dc.description.sponsorshipIDFAPESP: 2012/03056-4
dc.description.sponsorshipIDFAPESP: 2013/04970-4
dc.description.sponsorshipIDCNPq: 304205/2011-7
dc.description.sponsorshipIDCNPq: 406609/2015-2
dc.description.sponsorshipIDCAPES: 3095/2015-00
dc.format.extent1-10
dc.identifierhttp://dx.doi.org/10.1152/japplphysiol.00557.2016
dc.identifier.citationJournal Of Applied Physiology. Bethesda, v. 122, n. 1, p. 1-10, 2017.
dc.identifier.doi10.1152/japplphysiol.00557.2016
dc.identifier.issn8750-7587
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56450
dc.identifier.wosWOS:000393698000001
dc.language.isoeng
dc.publisherAmer Physiological Soc
dc.relation.ispartofJournal Of Applied Physiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectmotor complexity exerciseen
dc.subjectpresynaptic inhibitionen
dc.subjectdisynaptic reciprocal inhibitionen
dc.subjectdescending driveen
dc.subjectproprioceptionen
dc.titleResistance training with instability is more effective than resistance training in improving spinal inhibitory mechanisms in Parkinson's diseaseen
dc.typeinfo:eu-repo/semantics/article
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