The papain pocket delivery impairs the capsule fibrous healing around textured silicone implants in rats.

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dc.contributor.authorMoreira, Marcio [UNIFESP]
dc.contributor.authorFagundes, Djalma Jose [UNIFESP]
dc.contributor.authorLong, Charles A.
dc.contributor.authorAnninos, Photios
dc.contributor.authorPham, Tuan
dc.contributor.authorAnastassopoulos, George
dc.contributor.authorMastorakis, Nikos E.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T11:27:12Z
dc.date.available2018-06-18T11:27:12Z
dc.date.issued2009-01-01
dc.description.abstractTo study the tissue repair around the textured mammary implants under the action of papain (PA). Methods: Thirty-six Wistar rats were evaluated and randomly distributed into two groups (n = 18): papain (PA) and control (CT). Each group was equally distributed into 3 subgroups (n = 6) and observed on seventh, thirtieth-fifth and ninth pos-operative days. Each animal received a textured implant in the left dorso-axillary region (sham - SH), on were instilled 0.5 mL saline solution 0.9%, and another textured implant on the right dorso-axillary region (papain - PA), on were instilled 0.5 mL of water-soluble solution of papain. The control group (CT) received only textured implant in the left dorso-axillary region with prior instillation of 0.5 mL of saline solution 0.9%. The histological analysis of the 3 subgroups was carried out using picrosirius-red stain and an image analyzing system using the Image Pro Plus (TM) program to evaluate the thickness and maturation and deposition of collagen fibers. Immunohistochemical evaluation was performed, using micrometric reticules of Weiss (Olympus Labstore (TM)), for myofibroblasts counting only in the 90(th) day subgroup. Results: At 35(th) and 90(th) days, the papain group (PA) presented reduction on the fibrous capsule thickness around the implant, in the number of collagen fibers and myofibroblasts, comparing to the control group (CT). Conclusion: The papain drug decreased the fibrous capsule formation around the textured silicon implants in rats.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Surg, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Surg, BR-04023900 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent148-153
dc.identifierhttp://www.wseas.us/e-library/conferences/2009/moscow/BEBI/BEBI24.pdf?CFID=717212942&CFTOKEN=29430700
dc.identifier.citationProceedings Of The 2nd Wseas International Conference On Biomedical Electronics And Biomedical Informatics. Athens: World Scientific And Engineering Acad And Soc, p. 148-153, 2009.
dc.identifier.issn1790-5125
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45130
dc.identifier.wosWOS:000273246200024
dc.language.isoeng
dc.publisherWorld Scientific And Engineering Acad And Soc
dc.relation.ispartofProceedings Of The 2nd Wseas International Conference On Biomedical Electronics And Biomedical Informatics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMammary implanten
dc.subjectcapsular contractureen
dc.subjectinflammationen
dc.subjectcapsular thicknessen
dc.titleThe papain pocket delivery impairs the capsule fibrous healing around textured silicone implants in rats.en
dc.typeinfo:eu-repo/semantics/conferenceObject
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