Neuropeptide-Y immunoreactivity in the pilocarpine model of temporal lobe epilepsy

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dc.contributor.authorLurton, D.
dc.contributor.authorCavalheiro, E. A.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:30:24Z
dc.date.available2016-01-24T12:30:24Z
dc.date.issued1997-08-01
dc.description.abstractNeuropeptide-Y (NPY) is expressed by granule cells and messy fibres of the hippocampal dentate gyrus during experimental temporal lobe epilepsy (TLE). This expression may represent an endogenous damping mechanism since NPY has been shown to block seizure-like events following high-frequency stimulation in hippocampal slices. the pilocarpine (PILO) model of epilepsy is characterized by an acute period of status epilepticus followed by spontaneous recurrent seizures and related brain damage. We report peroxidase-antiperoxidase immunostaining for NPY in several brain regions in this model. PILO-injected animals exhibited NPY immunoreactivity in the region of the messy fibre terminals, in the dentate gyrus inner molecular layer and, in a few cases, within presumed granule cells. NPY immunoreactivity was also dramatically changed in the entorhinal cortex, amygdala and sensorimotor areas. in addition, PILO injected animals exhibited a reduction in the number of NPY-immunoreactive interneurons compared with controls. the results demonstrate that changes in NPY expression, including expression in the granule cells and messy fibres and the loss of vulnerable NPY neurons, are present in the PILO model of TLE. However, the significance of this changed synthesis of NPY remains to be determined.en
dc.description.affiliationUNIFESP,ESCOLA PAULISTA MED,São Paulo,BRAZIL
dc.description.affiliationUnifespUNIFESP,ESCOLA PAULISTA MED,São Paulo,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent186-190
dc.identifierhttp://dx.doi.org/10.1007/PL00005739
dc.identifier.citationExperimental Brain Research. New York: Springer Verlag, v. 116, n. 1, p. 186-190, 1997.
dc.identifier.doi10.1007/PL00005739
dc.identifier.issn0014-4819
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25767
dc.identifier.wosWOS:A1997XT50300021
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofExperimental Brain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectpilocarpineen
dc.subjectNPYen
dc.subjecthippocampusen
dc.subjectepilepsyen
dc.subjectimmunohistochemistryen
dc.subjectraten
dc.titleNeuropeptide-Y immunoreactivity in the pilocarpine model of temporal lobe epilepsyen
dc.typeinfo:eu-repo/semantics/article
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