Use of Color Doppler Ultrasonography for the Prediction of Malignancy in Follicidar Thyroid Neoplasms Systematic Review and Meta-analysis

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dc.contributor.authorIared, Wagner [UNIFESP]
dc.contributor.authorShigueoka, David Carlos [UNIFESP]
dc.contributor.authorCristofoli, Julio Cesar
dc.contributor.authorAndriolo, Regis Bruni [UNIFESP]
dc.contributor.authorAtallah, Álvaro Nagib [UNIFESP]
dc.contributor.authorAjzen, Sergio Aron [UNIFESP]
dc.contributor.authorValente, Orsine [UNIFESP]
dc.contributor.institutionABC Med Sch
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T10:54:31Z
dc.date.available2018-06-18T10:54:31Z
dc.date.issued2010-03-01
dc.description.abstractObjective. The purpose of this systematic review was to obtain summary estimates of the diagnostic accuracy of color Doppler ultrasonography (CDU) in predicting malignancy in thyroid follicular neoplasms (FNs). Methods. We searched Medical Subject Headings together with the search terms follicular, thyroid, and Doppler in the MEDLINE, Web of Science, and Excerpta Medica databases as well as the Latin American and Caribbean Health Sciences Literature database, after which we performed manual searches of the reference lists to locate additional studies. There were no language restrictions. We included studies that assessed the diagnostic accuracy of CIDU in identifying malignancy in thyroid FNs. The assessments of the quality and extraction of data were performed by 3 independent reviewers. Results. We included 4 studies, which collectively evaluated 457 thyroid FNs, 67 of which had been classified as malignant based on the evaluation of surgical biopsy samples. Moderate, rich, predominant, or exclusive internal flow on CIDU of thyroid FNs was considered indicative of malignancy. The overall sensitivity of CDU was 85% (95% confidence interval [CI], 74%-93%), with an overall specificity of 86% (95% CI, 82%-89%). The overall prevalence was 14.7%, and the positive and negative predictive values were 51% and 97%, respectively. The positive likelihood ratio was 6.07, and the negative likelihood ratio was 0.18. Conclusions. Predominant internal flow seen on CIDU is associated with malignancy of thyroid FNs. Absence of internal flow or predominantly peripheral flow indicates a low probability of thyroid FN malignancy.en
dc.description.affiliationBrazilian Cochrane Ctr, Dept Internal Med, BR-04038000 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Diagnost Imaging, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Diagnost Imaging, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent501-503
dc.identifierhttp://dx.doi.org/10.7863/jum.2010.29.3.419
dc.identifier.citationJournal Of Ultrasound In Medicine. Laurel: Amer Inst Ultrasound Medicine, v. 29, n. 3, p. 419-425, 2010.
dc.identifier.doi10.7863/jum.2010.29.3.419
dc.identifier.issn0278-4297
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44773
dc.identifier.wosWOS:000275685900010
dc.language.isoeng
dc.publisherAmer Inst Ultrasound Medicine
dc.relation.ispartofJournal Of Ultrasound In Medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcolor Doppler ultrasonographyen
dc.subjectfine-needle biopsyen
dc.subjectfollicular neoplasmen
dc.titleUse of Color Doppler Ultrasonography for the Prediction of Malignancy in Follicidar Thyroid Neoplasms Systematic Review and Meta-analysisen
dc.typeinfo:eu-repo/semantics/article
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