A very strict guideline reduces the number of erythrocyte transfusions in preterm infants

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dc.contributor.authorMimica, A. F. M. A. [UNIFESP]
dc.contributor.authorDos Santos, Amelia Miyashiro [UNIFESP]
dc.contributor.authorCunha, Deise Helena Fernandes da [UNIFESP]
dc.contributor.authorGuinsburg, Ruth [UNIFESP]
dc.contributor.authorBordin, J. O. [UNIFESP]
dc.contributor.authorChiba, A. [UNIFESP]
dc.contributor.authorBarros, M. M. O. [UNIFESP]
dc.contributor.authorKopelman, Benjamin Israel [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:26Z
dc.date.available2016-01-24T13:49:26Z
dc.date.issued2008-01-01
dc.description.abstractBackground and Objectives Benefits of adopting restrictive guidelines for erythrocyte transfusions are still controversial. the objective of this study was to verify if a very strict guideline could reduce erythrocyte transfusions in preterm infants without adverse outcomes.Materials and Methods Two prospective cohorts of neonates with gestational age < 37 weeks and birth weight < 1500 g were studied. Neonates born in Period 1 were submitted to a strict guideline for erythrocyte transfusions. in Period 2, a new stricter protocol was introduced. Infants of both periods were compared regarding number of transfusions and clinical outcome.Results the median number of transfusions decreased from 2 (1 to 14) in Period 1 to 1 (1-9), P = 0.001, in Period 2. the linear regression multivariate analysis showed that the implementation of the stricter guideline was associated with a reduction in the number of transfusions received by patients by 0.55 (95% confidence interval: -0.08; -1.02) units/patients. Number of apnea episodes, weight at 28 days of life and days of hospital stay were similar in both periods. Intra-hospital death was lower in Period 2.Conclusion A very strict guideline reduced the number of erythrocyte transfusions in preterm infants, without threatening their clinical course.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pediat, Div Neonatal Med, BR-04037002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Div Hematol & Hemotherapy, BR-04037002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pediat, Div Neonatal Med, BR-04037002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Div Hematol & Hemotherapy, BR-04037002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent106-111
dc.identifierhttp://dx.doi.org/10.1111/j.1423-0410.2008.01072.x
dc.identifier.citationVox Sanguinis. Hoboken: Wiley-Blackwell, v. 95, n. 2, p. 106-111, 2008.
dc.identifier.doi10.1111/j.1423-0410.2008.01072.x
dc.identifier.issn0042-9007
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30342
dc.identifier.wosWOS:000257499500004
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofVox Sanguinis
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectanaemiaen
dc.subjecterythrocyte transfusionen
dc.subjectinfanten
dc.subjectnewbornen
dc.subjectprematureen
dc.subjectred blood cellsen
dc.titleA very strict guideline reduces the number of erythrocyte transfusions in preterm infantsen
dc.typeinfo:eu-repo/semantics/article
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