Is hepatitis C more aggressive in renal transplant patients than in patients with end-stage renal disease?

Página do item simplificado
dc.contributor.authorPerez, R. M.
dc.contributor.authorFerreira, ASP
dc.contributor.authorMedina-Pestana, J. O.
dc.contributor.authorCendoroglo Neto, Miguel [UNIFESP]
dc.contributor.authorLanzoni, V. P.
dc.contributor.authorSilva, AEB
dc.contributor.authorFerraz, MLG
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:10Z
dc.date.available2016-01-24T12:41:10Z
dc.date.issued2006-05-01
dc.description.abstractBackground: the eventual impact of immunosuppression on the natural history of hepatitis C virus (HCV) infection in patients with end-stage renal disease (ESRD) is still unknown because of the lack of comparative data for HCV-infected patients with ESRD and renal transplant patients. the aim of this study was to compare the biochemical and histological characteristics of chronic HCV infection in renal transplants patients and ESRD patients undergoing hemodialysis.Methods: Thirty-eight renal transplant patients and 38 ESRD patients undergoing hemodialysis who were chronically infected with HCV and were matched for gender, age at infection, and estimated time of infection were included in the study. the groups were compared regarding laboratory and histological variables.Results: Renal transplant patients showed similar alanine aminotransferase and higher gamma-glutamyltransferase levels (P = 0.05) when compared with ESRD patients. Comparative analysis of histological variables revealed a higher proportion of cases with septal fibrosis (P = 0.04) and confluent necrosis (P = 0.01) among transplant-recipient patients. No difference between groups was observed regarding the intensity of portal and periportal inflammatory infiltrates. Steatosis was more prevalent among transplant-recipient patients (P < 0.001). There was no difference between groups regarding the prevalence of lymphoid aggregates or bile duct injury.Conclusion: Renal transplant patients had a larger proportion of cases with septal fibrosis and confluent necrosis than did ESRD patients, suggesting that renal transplantation might modify the natural history of hepatitis C in ESRD patients, leading to a more aggressive liver disease.en
dc.description.affiliationUniv Fed Rio de Janeiro, Dept Internal Med, BR-21941 Rio de Janeiro, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Nephrol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent444-448
dc.identifierhttp://dx.doi.org/10.1097/00004836-200605000-00016
dc.identifier.citationJournal of Clinical Gastroenterology. Philadelphia: Lippincott Williams & Wilkins, v. 40, n. 5, p. 444-448, 2006.
dc.identifier.doi10.1097/00004836-200605000-00016
dc.identifier.issn0192-0790
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28896
dc.identifier.wosWOS:000237742900016
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal of Clinical Gastroenterology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectend-stage renal disease (ESRD)en
dc.subjecthemodialysisen
dc.subjecthepatitis Cen
dc.subjectkidney transplantationen
dc.subjectliver biopsyen
dc.titleIs hepatitis C more aggressive in renal transplant patients than in patients with end-stage renal disease?en
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
Em verificação - Geral