Is there a role for urinary podocyte excretion assessment in lupus nephritis?

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dc.citation.issue4
dc.citation.volume38
dc.contributor.authorMansur, Juliana Busato [UNIFESP]
dc.contributor.authorSabino, Amelia Rodrigues Pereira [UNIFESP]
dc.contributor.authorNishida, Sonia Kiyomi [UNIFESP]
dc.contributor.authorKirsztajn, Gianna Mastroianni [UNIFESP]
dc.coverageAbingdon
dc.date.accessioned2020-07-22T13:23:07Z
dc.date.available2020-07-22T13:23:07Z
dc.date.issued2016
dc.description.abstractObjective To establish the occurrence and intensity of podocyturia and its relation to grade of disease activity, as defined by clinical and laboratory criteria. Methods Prospective, cross-sectional study involving 50 patients with lupus nephritis and 29 controls, which had podocyturia levels determined from random urine samples using an immunofluorescence technique. Disease activity was graded by BILAG (renal criteria) and an additional system used in the service (S2). Results Fifty patients with lupus nephritis (WHO classes III, IV and V), with a median age of 37years, were evaluated. Of these, 86.5% were female, and 52% were BILAG A. Podocyturia quantification in the lupus nephritis and control groups differed significantly (p = 0.009). This score was higher in relation to classes III, IV and V. The correlation with C3 consumption was stronger (p = 0.011) than with C4. The highest levels were found in the most active groups (A and B of BILAG and S2). Lower podocyturia correlated with a lower dose of prednisone. There was no association with the intensity of proteinuria, hematuria or pyuria, serum creatinine levels, among others. Conclusions Podocyturia assessment, which was performed by immunofluorescence in this study, can be used as an indicator of disease activity with the advantage of being a urinary biomarker. The levels proved to be higher in patients with lupus nephritis than in the controls and were particularly higher in class IV.en
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Div Nephrol, Napoleao de Barros St 715, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP, Div Nephrol, Napoleao de Barros St 715, BR-04024002 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipBrazilian Council for Scientific and Technological Development (CNPq)
dc.format.extent643-647
dc.identifierhttp://dx.doi.org/10.3109/0886022X.2016.1150099
dc.identifier.citationRenal Failure. Abingdon, v. 38, n. 4, p. 643-647, 2016.
dc.identifier.doi10.3109/0886022X.2016.1150099
dc.identifier.issn0886-022X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56047
dc.identifier.wosWOS:000372164000022
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofRenal Failure
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGlomerulonephritisen
dc.subjectsystemic lupus erythematosusen
dc.subjectlupus nephritisen
dc.subjectpodocyturiaen
dc.subjectpodocytesen
dc.subjectproteinuriaen
dc.titleIs there a role for urinary podocyte excretion assessment in lupus nephritis?en
dc.typeinfo:eu-repo/semantics/article
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