A Possible role for Platelet-Activating Factor receptor in Amyotrophic Lateral sclerosis treatment

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dc.citation.volume9
dc.contributor.authorBriones, Marcelo R. S. [UNIFESP]
dc.contributor.authorSnyder, Amanda M.
dc.contributor.authorFerreira, Renata C. [UNIFESP]
dc.contributor.authorNeely, Elizabeth B.
dc.contributor.authorConnor, James R.
dc.contributor.authorBroach, James R.
dc.coverageLausanne
dc.date.accessioned2020-07-08T13:09:41Z
dc.date.available2020-07-08T13:09:41Z
dc.date.issued2018
dc.description.abstractAmyotrophic lateral sclerosis (ALS) is the third most prevalent neurodegenerative disease affecting upper and lower motor neurons. An important pathway that may lead to motor neuron degeneration is neuroinflammation. Cerebrospinal Fluids of ALS patients have increased levels of the inflammatory cytokine IL-18. Because IL-18 is produced by dendritic cells stimulated by the platelet-activating factor (PAF), a major neuroinflammatory mediator, it is expected that PAF is involved in ALS. Here we show pilot experimental data on amplification of PAF receptor (PAFR) mRNA by RT-PCR. PAFR is overexpressed, as compared to age matched controls, in the spinal cords of transgenic ALS SOD1-G93A mice, suggesting PAF mediation. Although anti-inflammatory drugs have been tested for ALS before, no clinical trial has been conducted using PAFR specific inhibitors. Therefore, we hypothesize that administration of PAFR inhibitors, such as Ginkgolide B, PCA 4248 and WEB 2086, have potential to function as a novel therapy for ALS, particularly in SOD1 familial ALS forms. Because currently there are only two approved drugs with modest effectiveness for ALS therapy, a search for novel drugs and targets is essential.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Hlth Informat, Escola Paulista Med, Sao Paulo, SP, Brazil
dc.description.affiliationPenn State Coll Med, Inst Personalized Med, Dept Biochem, Hershey, PA 17033 USA
dc.description.affiliationPenn State Coll Med, Dept Neurosurg, Hershey, PA USA
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Neurol & Neurosurg, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Hlth Informat, Escola Paulista Med, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Neurol & Neurosurg, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipBrazilian government agencies FAPESP
dc.description.sponsorshipCNPq
dc.description.sponsorshipPennsylvania Department of Health using Tobacco CURE funds
dc.description.sponsorshipIDFAPESP: 2013/07838-0, 2014/25602-6
dc.description.sponsorshipIDCNPq: 303905/2013-1
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fneur.2018.00039
dc.identifier.citationFrontiers In Neurology. Lausanne, v. 9, p. -, 2018.
dc.identifier.doi10.3389/fneur.2018.00039
dc.identifier.fileWOS000424233400002.pdf
dc.identifier.issn1664-2295
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54141
dc.identifier.wosWOS:000424233400002
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Neurology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectamyotrophic lateral sclerosisen
dc.subjectplatelet-activating factoren
dc.subjectneuroinflammationen
dc.subjectanti-inflammatoryen
dc.subjectcytokinesen
dc.titleA Possible role for Platelet-Activating Factor receptor in Amyotrophic Lateral sclerosis treatmenten
dc.typeinfo:eu-repo/semantics/article
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