Diversity of pathways for intracellular angiotensin II synthesis

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dc.contributor.authorKumar, Rajesh
dc.contributor.authorBoim, Mirian A. [UNIFESP]
dc.contributor.institutionTexas A&M Hlth Sci Ctr
dc.contributor.institutionScott & White Mem Hosp & Clin
dc.contributor.institutionCent Texas Vet Healthcare Syst
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:52:07Z
dc.date.available2016-01-24T13:52:07Z
dc.date.issued2009-01-01
dc.description.abstractPurpose of reviewThe renin-angiotensin system (RAS) has undergone continuous advancement since the initial identification of renin as a pressor agent. Traditionally considered a circulatory system, the RAS is now known to exist as a tissue system as well. Recently, the tissue RAS has been further categorized as intracellular and extracellular. Owing to the unique location, the intracellular RAS encompasses new components, such as cathepsin D and chymase, which participate in intracellular angiotensin (Ang) II synthesis. in this review, evidence of the intracellular RAS and the mechanism of Ang II synthesis in various cell types will be discussed.Recent findingsA physiological role for intracellular Ang II in vascular and cardiac cells has recently been demonstrated. Evidence of intracellular Ang II generation has been shown in several cell types, particularly cardiac, renal, and vascular. Importantly, intracellular synthesis of Ang II is more prominent in hyperglycemic conditions and generally involves angiotensin-converting enzyme-dependent and angiotensin-converting enzyme-independent mechanisms,SummaryThere is significant diversity in the mechanism of intracellular synthesis of Ang II in various cell types and pathological conditions. These observations suggest that a therapeutic intervention to block the RAS should take into consideration the nature of the disorder and the cell type involved.en
dc.description.affiliationTexas A&M Hlth Sci Ctr, Coll Med, Dept Med, Div Mol Cardiol, Temple, TX 76504 USA
dc.description.affiliationScott & White Mem Hosp & Clin, Temple, TX USA
dc.description.affiliationCent Texas Vet Healthcare Syst, Temple, TX USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Div Renal, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Div Renal, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent33-39
dc.identifierhttp://dx.doi.org/10.1097/MNH.0b013e32831a9e20
dc.identifier.citationCurrent Opinion in Nephrology and Hypertension. Philadelphia: Lippincott Williams & Wilkins, v. 18, n. 1, p. 33-39, 2009.
dc.identifier.doi10.1097/MNH.0b013e32831a9e20
dc.identifier.issn1062-4821
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31204
dc.identifier.wosWOS:000262323300007
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofCurrent Opinion in Nephrology and Hypertension
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectangiotensin-converting enzymeen
dc.subjectchymaseen
dc.subjectdiabetesen
dc.subjectintracrineen
dc.subjectreninen
dc.subjectrenin-angiotensin systemen
dc.titleDiversity of pathways for intracellular angiotensin II synthesisen
dc.typeinfo:eu-repo/semantics/article
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