Chronic resistance training decreases MuRF-1 and Atrogin-1 gene expression but does not modify Akt, GSK-3 beta and p70S6K levels in rats

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dc.contributor.authorZanchi, Nelo Eidy
dc.contributor.authorSiqueira Filho, Mario Alves de
dc.contributor.authorLira, Fabio Santos [UNIFESP]
dc.contributor.authorRosa, Jose Cesar [UNIFESP]
dc.contributor.authorYamashita, Alex Shimura
dc.contributor.authorOliveira Carvalho, Carla Roberta de
dc.contributor.authorSeelaender, Marilia
dc.contributor.authorLancha, Antonio Herbert
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:52:34Z
dc.date.available2016-01-24T13:52:34Z
dc.date.issued2009-06-01
dc.description.abstractLong-term adaptation to resistance training is probably due to the cumulative molecular effects of each exercise session. Therefore, we studied in female Wistar rats the molecular effects of a chronic resistance training regimen (3 months) leading to skeletal muscle hypertrophy in the plantaris muscle. Our results demonstrated that muscle proteolytic genes MuRF-1 and Atrogin-1 were significantly decreased in the exercised group measured 24 h after the last resistance exercise session (41.64 and 61.19%, respectively; P < 0.05). Nonetheless, when measured at the same time point, 4EBP-1, GSK-3 beta and eIF2B epsilon mRNA levels and Akt, GSK-3 beta and p70S6K protein levels (regulators of translation initiation) were not modified. Such data suggests that if gene transcription constitutes a control point in the protein synthesis pathway this regulation probably occurs in early adaptation periods or during extreme situations leading to skeletal muscle remodeling. However, proteolytic gene expression is modified even after a prolonged resistance training regimen leading to moderate skeletal muscle hypertrophy.en
dc.description.affiliationUniv São Paulo, Phys Educ & Sport Sch, Lab Appl Nutr & Metab, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Mol Biol Cell Grp, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Nutr Physiol, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Nutr Physiol, Dept Physiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 08/51090-1
dc.format.extent415-423
dc.identifierhttp://dx.doi.org/10.1007/s00421-009-1033-6
dc.identifier.citationEuropean Journal of Applied Physiology. New York: Springer, v. 106, n. 3, p. 415-423, 2009.
dc.identifier.doi10.1007/s00421-009-1033-6
dc.identifier.issn1439-6319
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31546
dc.identifier.wosWOS:000266496400011
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofEuropean Journal of Applied Physiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectHypertrophyen
dc.subjectProtein synthesisen
dc.subjectProteolysisen
dc.subjectSkeletal muscleen
dc.titleChronic resistance training decreases MuRF-1 and Atrogin-1 gene expression but does not modify Akt, GSK-3 beta and p70S6K levels in ratsen
dc.typeinfo:eu-repo/semantics/article
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