Effect of severe neonatal seizures on prepulse inhibition and hippocampal volume of rats tested in early adulthood

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dc.contributor.authorLabbate, Giovanna Puosso [UNIFESP]
dc.contributor.authorSilva, Alexandre Valotta da [UNIFESP]
dc.contributor.authorSilva, Regina Cláudia Barbosa da [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:37:17Z
dc.date.available2016-01-24T14:37:17Z
dc.date.issued2014-05-07
dc.description.abstractSeveral lines of evidence indicate that the risk of developing schizophrenia is significantly enhanced following postnatal exposure to environmental insults occurring during the critical periods of early central nervous system development. the hippocampus is a brain structure that has been associated with the neuropathology of schizophrenia. Neonatal epileptic seizures in rat pups can affect the construction of hippocampal networks. Patients with schizophrenia exhibit deficits in an operational measure of sensorimotor gating: prepulse inhibition (PPI) of startle. PPI is the normal reduction in the startle response caused by a low intensity non-startling stimulus (prepulse) which is presented shortly before the startle stimulus (pulse). the aim of the present study was to investigate if prolonged epileptic seizures, occurring during postnatal brain development, alter prepulse inhibition (PPI) response of acoustic startle reflex and hippocampal volume of rats tested later in life (post-pubertal phase). Pilocarpine-induced status epilepticus (SE) was induced in postnatal days (PNDs) 7-9 in rat pups. On PND56, the animals were tested in the acoustic startle/PPI paradigm. Hippocampal volume was measured in histological brain slices using the Cavalieri's principle. Dorsal and ventral hippocampi were measured bilaterally. Our results demonstrate that animals subjected to SE presented deficits in PPI when tested in adulthood. Dorsal hippocampal volume was reduced in rats that experienced severe neonatal seizures. (C) 2014 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biociencias, Lab Psicol Expt, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biociencias, Lab Psicol Expt, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipIDCNPq: 121490/2009-2pt
dc.description.sponsorshipIDCNPq: 111984/2010-6pt
dc.format.extent62-66
dc.identifierhttps://dx.doi.org/10.1016/j.neulet.2014.03.019
dc.identifier.citationNeuroscience Letters. Clare: Elsevier B.V., v. 568, p. 62-66, 2014.
dc.identifier.doi10.1016/j.neulet.2014.03.019
dc.identifier.issn0304-3940
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/37765
dc.identifier.wosWOS:000336114000012
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Letters
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectEarly insulten
dc.subjectNeurodevelopmenten
dc.subjectPrepulse inhibitionen
dc.subjectHippocampusen
dc.subjectSchizophreniaen
dc.subjectRaten
dc.titleEffect of severe neonatal seizures on prepulse inhibition and hippocampal volume of rats tested in early adulthooden
dc.typeinfo:eu-repo/semantics/article
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