Subtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Rats

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dc.citation.volume10
dc.contributor.authorMacedo, Priscila Tavares
dc.contributor.authorAquino, Antônio Carlos Queiroz de
dc.contributor.authorMeurer, Ywlliane da Silva Rodrigues [UNIFESP]
dc.contributor.authorBrandão, Luiz Eduardo Mateus
dc.contributor.authorCampelo, Clarissa Loureiro Chagas
dc.contributor.authorLima, Ramon Hypólito
dc.contributor.authorCosta, Marcos R.
dc.contributor.authorRibeiro, Alessandra Mussi [UNIFESP]
dc.contributor.authorSilva, Regina Helena [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.coverageLausanne
dc.date.accessioned2020-07-08T13:09:51Z
dc.date.available2020-07-08T13:09:51Z
dc.date.issued2018
dc.description.abstractThe cause of Alzheimer’s disease (AD) remains uncertain. The accumulation of amyloid peptides (Aβ) is the main pathophysiological hallmark of the disease. Spatial deficit is an important initial sign of AD, while other types of memory impairments that appear in later stages. The Barnes maze allows the detection of subtle alterations in spatial search by the analysis of use of different strategies. Previous findings showed a general performance deficit in this task following long-term (35 days) infusion of Aβ, which corresponds to the moderate or severe impairments of the disease. In the present study, we evaluated the effects of a low-dose 15-day long treatment with Aβ peptides on spatial and non-spatial strategies of rats tested in the Barnes maze. Aβ peptides (0.5 μL/site/day; 30 pmoL solution of Aβ1–40:Aβ1–42 10:1) or saline were bilaterally infused into the CA1 (on the first treatment day) and intraventricularly (on the following 15 days) in 6-month-old Wistar male rats. Aβ infusion induced a deficit in the performance (increased latency and distance traveled to reach the target compared to saline group). In addition, a significant association between treatment and search strategy in the retrieval trial was found: Aβ group preferred the non-spatial search strategy, while saline group preferred the spatial search. In conclusion, the protocol of Aβ infusion used here induced a subtle cognitive deficit that was specific to spatial aspects. Indeed, animals under Aβ treatment still showed retrieval, but using non-spatial strategies. We suggest that this approach is potentially useful to the study of the initial memory deficits in early AD.en
dc.description.affiliationUniv Fed Rio Grande do Norte, Physiol Dept, Memory Studies Lab, Natal, RN, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Brain Inst, Natal, RN, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Pharmacol Dept, Behav Neurosci Lab, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biosci, Lab Neurosci & Bioprospecting Nat Prod, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Pharmacol Dept, Behav Neurosci Lab, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biosci, Lab Neurosci & Bioprospecting Nat Prod, Sao Paulo, Brazil
dc.description.provenanceMade available in DSpace on 2020-07-08T13:09:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2018. Added 1 bitstream(s) on 2020-07-08T13:33:35Z : No. of bitstreams: 1 WOS000423549500002.pdf: 1539788 bytes, checksum: fa37d683c1e5d1fcb3284602b3b2ad61 (MD5)en
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt
dc.description.sponsorshipFundação de Apoio à Pesquisa do Estado do Rio Grande do Norte (FAPERN/PRONEX)pt
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipIDCNPq: 402054/2010-5pt
dc.description.sponsorshipIDFAPESP: 2015/12308-5pt
dc.format.extent-
dc.identifierhttps://dx.doi.org/10.3389/fnagi.2018.00018
dc.identifier.citationFrontiers In Aging Neuroscience. Lausanne, v. 10, p. -, 2018.
dc.identifier.doi10.3389/fnagi.2018.00018
dc.identifier.fileWOS000423549500002.pdf
dc.identifier.issn1663-4365
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54247
dc.identifier.wosWOS:000423549500002
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Aging Neuroscience
dc.rightsAcesso aberto
dc.subjectNeurodegenerative diseaseen
dc.subjectBeta-amyloid peptideen
dc.subjectBarnes mazeen
dc.subjectNavigationen
dc.subjectStrategyen
dc.titleSubtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Ratsen
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