Does the increase in locomotion induced by ethanol indicate its stimulant or anxiolytic properties?

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dc.contributor.authorBoerngen-Lacerda, R.
dc.contributor.authorSouza-Formigoni, MLO
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Parana
dc.date.accessioned2016-01-24T12:31:11Z
dc.date.available2016-01-24T12:31:11Z
dc.date.issued2000-10-01
dc.description.abstractThe responses of mice to low doses of acutely and chronically administered ethanol (2.0 g/kg) and diazepam (2.0 mg/kg) were observed in the activity cages, the open field and the elevated plus-maze. After prolonged administration, ethanol significantly increased locomotion in the activity cages and the plus-maze. in the open field, an increase was only observed in the tests performed after 7 and 14 days of treatment. Ethanol increased the open-arm time in the plus-maze in all the tests, including after acute administration, suggesting an anxiolytic effect. Diazepam induced an anxiolytic effect after 14 days of daily injections but had no stimulant effect on locomotion. Moreover, after prolonged administration sensitization to the anxiolytic, but not to the stimulant effect, was observed. in short, the present paper's data support the hypothesis that the stimulant and anxiolytic effects of ethanol are probably being mediated by distinct mechanisms. Furthermore, these data support the hypothesis that drugs that lead to abusive use, such as ethanol, may act both as positive and negative reinforcement. (C) 2000 Elsevier Science Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Fed Parana, Sector Biol Sci, Dept Pharmacol, BR-81540970 Curitiba, Parana, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent225-232
dc.identifierhttp://dx.doi.org/10.1016/S0091-3057(00)00360-9
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 67, n. 2, p. 225-232, 2000.
dc.identifier.doi10.1016/S0091-3057(00)00360-9
dc.identifier.issn0091-3057
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26391
dc.identifier.wosWOS:000166046200003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectethanolen
dc.subjectdiazepamen
dc.subjectsensitizationen
dc.subjecttoleranceen
dc.subjectanxietyen
dc.subjectlocomotor activityen
dc.subjectstimulationen
dc.subjectreinforcing propertiesen
dc.subjectelevated plus-mazeen
dc.subjectopen-field miceen
dc.titleDoes the increase in locomotion induced by ethanol indicate its stimulant or anxiolytic properties?en
dc.typeinfo:eu-repo/semantics/article
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