Green Coffea arabica L. seed oil influences the stability and protective effects of topical formulations

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dc.contributor.authorWagemaker, Tais A. L.
dc.contributor.authorSilva, Silas A. M. [UNIFESP]
dc.contributor.authorLeonardi, Gislaine R. [UNIFESP]
dc.contributor.authorMaia Campos, Patricia M. B. G.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:39:50Z
dc.date.available2016-01-24T14:39:50Z
dc.date.issued2015-01-01
dc.description.abstractGreen Coffea arabica L. seed oil (GCO) has been used as an active ingredient in many skin care products, due to its properties as an emollient, improver of skin hydration and absorbent of UVB radiation. However, to obtain a stable, effective and pleasant formulation containing variable amounts of GCO it is necessary to know specific chemical characteristics of the combined ingredients. Thus, this study evaluated rheological behavior, presence of liquid crystals (LCs) and skin protective effects of GCO-containing formulations aiming to correlate these parameters with GCO concentrations by using a principal component analysis (PCA). Formulations containing GCO or not (0-15%) were submitted to physical stability assays by determinations of rheological behavior after 90 days storage, detection of LCs by polarized light microscopy and in vitro determination of the sun protection factor (SPF). in vivo protective effects in mice were evaluated with biophysical techniques and histological analysis. Data were correlated using PCA. Despite the low SPF values, GCO addition to formulations resulted in significant and proportional increases of these values. It is concluded that formulation stability and skin protective properties are influenced by GCO but desirable effects are only possible when GCO is present in high concentrations. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv São Paulo, Fac Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, Brazil
dc.description.affiliationUNIFESP, Inst Environm Chem & Pharmaceut Sci, Diadema, SP, Brazil
dc.description.affiliationUnifespUNIFESP, Inst Environm Chem & Pharmaceut Sci, Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2009/14031-0
dc.format.extent34-40
dc.identifierhttp://dx.doi.org/10.1016/j.indcrop.2014.09.045
dc.identifier.citationIndustrial Crops and Products. Amsterdam: Elsevier B.V., v. 63, p. 34-40, 2015.
dc.identifier.doi10.1016/j.indcrop.2014.09.045
dc.identifier.issn0926-6690
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38588
dc.identifier.wosWOS:000347499000005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofIndustrial Crops and Products
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectGreen coffee oilen
dc.subjectRheological behavioren
dc.subjectLiquid crystalsen
dc.subjectBiophysical techniquesen
dc.subjectSun protection factoren
dc.subjectPCAen
dc.titleGreen Coffea arabica L. seed oil influences the stability and protective effects of topical formulationsen
dc.typeinfo:eu-repo/semantics/article
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