Does mesenchymal stem cell improve the liver regeneration after the 70% hepatectomy?]

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dc.citation.issue7]
dc.citation.volume32]
dc.contributor.authorSoares Alves, Ana Karina [UNIFESP]
dc.contributor.authorLanzoni, Valeria [UNIFESP]
dc.contributor.authorFuziy, Rogerio Aoki [UNIFESP]
dc.contributor.authorMonteiro Moura Franco, Rita Maria Aparecida [UNIFESP]
dc.contributor.authorMaeda, Carlos Toshinori [UNIFESP]
dc.contributor.authorLopes Filho, Gaspar de Jesus [UNIFESP]
dc.contributor.authorLinhares, Marcelo Moura [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-06-26T16:30:27Z
dc.date.available2020-06-26T16:30:27Z
dc.date.issued2017
dc.description.abstractPurpose: To evaluate the effects of mesenchymal stem cells on liver regeneration in rats following a 70% hepatectomy. Methods: Forty rats were subjected to 70% hepatectomy and then similar to 10(6) mesenchymal stem cells (test group), or saline solution (control group), were infused into their livers via the portal vein. Each treatment group was divided into early and late subgroups (euthanized 3 d and 5 d following the operation, respectively). Group comparisons of Albumin, aminotransaminases (AST, ALT), and Alcaline Phosphatase (AP) levels, proliferative index (ki-67+ straining), and mitotic cell counts were conducted. Results: No significant differences in liver regeneration rate, number of mitoses, proliferative index, or serum levels of albumin, AST, or AP were observed. ALT levels were higher in the test group than in the control group (p<.05). Conclusions: Mesenchymal stem-cell therapy did not improve liver regeneration rate 3 d or 5 d after 70% hepatectomy in rats. Likewise, the therapy appeared not to affect liver function, proliferative index, or number of mitoses significantly.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Postgrad Program Interdisciplinary Surg Sci, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pathol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Surg, Div Surg Gastroenterol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Postgrad Program Interdisciplinary Surg Sci, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pathol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Surg, Div Surg Gastroenterol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent515-522
dc.identifierhttp://dx.doi.org/10.1590/s0102-865020170070000002]
dc.identifier.citationActa Cirurgica Brasileira. Sao Paulo, v. 32, n. 7, p. 515-522, 2017.
dc.identifier.doi10.1590/s0102-865020170070000002
dc.identifier.fileS0102-86502017000700515.pdf
dc.identifier.issn0102-8650
dc.identifier.scieloS0102-86502017000700515
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53549
dc.identifier.wosWOS:000407368300002
dc.language.isoeng
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMesenchymal Stem Cell Transplantationen
dc.subjectLiver Regenerationen
dc.subjectHepatectomyen
dc.subjectCell-and Tissue-Based Therapyen
dc.subjectRatsen
dc.titleDoes mesenchymal stem cell improve the liver regeneration after the 70% hepatectomy?]en
dc.typeinfo:eu-repo/semantics/article
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