Current concepts in the treatment of hereditary ataxias

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dc.citation.issue3
dc.citation.volume74
dc.contributor.authorBraga-Neto, Pedro [UNIFESP]
dc.contributor.authorPedroso, Jose Luiz [UNIFESP]
dc.contributor.authorKuo, Sheng-Han
dc.contributor.authorFranca Junior, Marcondes C.
dc.contributor.authorGhizoni Teive, Helio Afonso
dc.contributor.authorPovoas Barsottini, Orlando Graziani [UNIFESP]
dc.coverageSao Paulo Sp
dc.date.accessioned2020-08-21T17:00:02Z
dc.date.available2020-08-21T17:00:02Z
dc.date.issued2016
dc.description.abstractHereditary ataxias (HA) represents an extensive group of clinically and genetically heterogeneous neurodegenerative diseases, characterized by progressive ataxia combined with extra-cerebellar and multi-systemic involvements, including peripheral neuropathy, pyramidal signs, movement disorders, seizures, and cognitive dysfunction. There is no effective treatment for HA, and management remains supportive and symptomatic. In this review, we will focus on the symptomatic treatment of the main autosomal recessive ataxias, autosomal dominant ataxias, X-linked cerebellar ataxias and mitochondrial ataxias. We describe management for different clinical symptoms, mechanism-based approaches, rehabilitation therapy, disease modifying therapy, future clinical trials and perspectives, genetic counseling and preimplantation genetic diagnosis.en
dc.description.affiliationUniv Estadual Ceara, Ctr Hlth Sci, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Neurol & Neurocirurgia, Sao Paulo, SP, Brazil
dc.description.affiliationColumbia Univ, Dept Neurol, New York, NY USA
dc.description.affiliationUniv Estadual Campinas, Dept Neurol, Campinas, SP, Brazil
dc.description.affiliationUniv Fed Parana, Hosp Clin, Serv Neurol, BR-80060000 Curitiba, Parana, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Neurol & Neurocirurgia, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent244-252
dc.identifierhttp://dx.doi.org/10.1590/0004-282X20160038
dc.identifier.citationArquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 74, n. 3, p. 244-252, 2016.
dc.identifier.doi10.1590/0004-282X20160038
dc.identifier.fileS0004-282X2016000300012-en.pdf
dc.identifier.issn0004-282X
dc.identifier.scieloS0004-282X2016000300012
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57845
dc.identifier.wosWOS:000374191900012
dc.language.isoeng
dc.publisherAssoc Arquivos Neuro- Psiquiatria
dc.relation.ispartofArquivos De Neuro-Psiquiatria
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthereditary ataxiasen
dc.subjecttreatmenten
dc.subjectrehabilitation therapyen
dc.subjectdisease modifying therapyen
dc.titleCurrent concepts in the treatment of hereditary ataxiasen
dc.typeinfo:eu-repo/semantics/article
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