Uterine Artery Embolization and Surgical Methods for the Treatment of Symptomatic Uterine Leiomyomas: A Systemic Review and Meta-analysis Followed by Indirect Treatment Comparison

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dc.citation.issue7]
dc.citation.volume39]
dc.contributor.authorFonseca, Marcelo C. M. [UNIFESP]
dc.contributor.authorCastro, Rodrigo [UNIFESP]
dc.contributor.authorMachado, Marcio
dc.contributor.authorConte, Tania
dc.contributor.authorGirao, Manoel J. B. C. [UNIFESP]
dc.coverageBridgewater
dc.date.accessioned2020-06-26T16:30:28Z
dc.date.available2020-06-26T16:30:28Z
dc.date.issued2017
dc.description.abstractPurpose: There is significant discussion and uncertainty about the optimal management of symptomatic uterine leiomyomas (SULs). Nonsurgical procedures such as uterine artery embolization (UAE) have been developed. The goal of this study was to conduct a meta-analysis and an indirect treatment comparison to examine the comparative efficacy and safety of the surgical procedures to treat SULs compared with UAE. Methods: MEDLINE, EMBASE, Lilacs, and the Cochrane Central Register of Controlled Trials data-bases were searched from inception to February 2016. Ten randomized controlled trials comparing UAE versus hysterectomy, myomectomy, and laparoscopic occlusion of the uterine arteries in patients with SUL published in a peer-reviewed journal were included. Two reviewers independently selected studies, assessed quality, and extracted data. Discrepancies were resolved through consensus. Findings: Data from 986 patients submitted to UEA (n = 527) or surgery (n = 459) were analyzed. UAE had a lower risk of major complications (risk ratio [RR], 0.45 [95% CI, 0.22-0.95]en
dc.description.abstractP = 0.04)and a higher risk of minor complications (RR, 1.65 [95% CI, 1.32-2.06]en
dc.description.abstractP < 0.00001)en
dc.description.abstractUAE had a higher risk of re-intervention up to 2 years (RR, 3.74 [95% CI, 1.76-7.96]en
dc.description.abstractP = 0.0006) and up to 5 years (RR, 5.01 [95% CI, 1.37-18.39]en
dc.description.abstractP = 0.02)en
dc.description.abstractUAE had a similar risk of follicle-stimulating hormone levels > 40 IU/L after 6 months (RR, 1.76 [95% CI, 0.24-12.95]en
dc.description.abstractP = 0.58)and of recommending the procedure to another patient up to 5 years after treatment (RR, 1.00 [95% CI, 0.87-1.14]en
dc.description.abstractP = 0.94). The indirect comparison between myomectomy and hysterectomy found that the 2 procedures were similar in the studied outcomes. (C) 2017 Published by Elsevier HS Journals, Inc.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Gynecol, Rua Napoledo de Barros 632, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationBiogen Inc, Sao Paulo, Brazil
dc.description.affiliationUniv British Columbia, Ctr Clin Epidemiol & Evaluat, Vancouver, BC, Canada
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Gynecol, Rua Napoledo de Barros 632, BR-04024002 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1438-1455
dc.identifierhttp://dx.doi.org/10.1016/j.clinthera.2017.05.346]
dc.identifier.citationClinical Therapeutics. Bridgewater, v. 39, n. 7, p. 1438-1455, 2017.
dc.identifier.doi10.1016/j.clinthera.2017.05.346
dc.identifier.issn0149-2918
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53553
dc.identifier.wosWOS:000407187500015
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofClinical Therapeutics
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHysterectomyen
dc.subjectleiomyomaen
dc.subjectmeta-analysisen
dc.subjectuterine artery embolizationen
dc.subjectuterine myomectomyen
dc.titleUterine Artery Embolization and Surgical Methods for the Treatment of Symptomatic Uterine Leiomyomas: A Systemic Review and Meta-analysis Followed by Indirect Treatment Comparisonen
dc.typeinfo:eu-repo/semantics/article
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