Asymptomatic Ventricular Arrhythmia and Clinical Outcomes in Chronic Kidney Disease: A Pilot Study

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dc.citation.issue1
dc.citation.volume7
dc.contributor.authorBonato, Fabiana Oliveira Bastos [UNIFESP]
dc.contributor.authorWatanabe, Renato [UNIFESP]
dc.contributor.authorLemos, Marcelo Montebello [UNIFESP]
dc.contributor.authorCassiolato, Jose Luiz
dc.contributor.authorWolf, Myles
dc.contributor.authorCanziani, Maria Eugênia Fernandes [UNIFESP]
dc.coverageBasel
dc.date.accessioned2020-07-31T12:47:01Z
dc.date.available2020-07-31T12:47:01Z
dc.date.issued2017
dc.description.abstractBackground/Aims: Ventricular arrhythmia is associated with increased risk of cardiovascular events and death in the general population. Sudden death is a leading cause of death in end-stage renal disease. We aimed at evaluating the effects of ventricular arrhythmia on clinical outcomes in patients with earlier stages of chronic kidney disease (CKD). Methods: In a prospective study of 109 nondialyzed CKD patients (estimated glomerular filtration rate 34.8 +/- 16.1 ml/min/1.73 m(2), 57 +/- 11.4 years, 61% male, 24% diabetics), we tested the hypothesis that the presence of subclinical complex ventricular arrhythmia, assessed by 24-hour electrocardiogram, is associated with increased risks of cardiovascular events, hospitalization, and death and with their composite outcome during 24 months of follow-up. Complex ventricular arrhythmia was defined as the presence of multifocal ventricular extrasystoles, paired ventricular extrasystoles, nonsustained ventricular tachycardia, or R wave over T wave. Results: We identified complex ventricular arrhythmia in 14% of participants at baseline. During follow-up, 11 cardiovascular events, 15 hospitalizations, and 4 deaths occurred. The presence of complex ventricular arrhythmia was associated with cardiovascular events (p < 0.001), hospitalization (p = 0.018), mortality (p < 0.001), and the composite outcome (p < 0.001). In multivariate Cox regression analysis, adjusting for demographic characteristics, complex ventricular arrhythmia was associated with increased risk of the composite outcome (HR 4.40en
dc.description.abstract95% CI 1.60-12.12en
dc.description.abstractp = 0.004). Conclusion: In this pilot study, the presence of asymptomatic complex ventricular arrhythmia was associated with poor clinical outcomes in nondialyzed CKD patients. (C) 2016 S. Karger AG, Baselen
dc.description.affiliationUniv Fed Sao Paulo, Div Nephrol, Dept Internal Med, Rua Pedro Toledo 282, BR-04039000 Sao Paulo, SP, Brazil
dc.description.affiliationCardios Res Inst, Sao Paulo, Brazil
dc.description.affiliationNorthwestern Univ, Feinberg Sch Med, Div Nephrol & Hypertens, Dept Med, Chicago, IL 60611 USA
dc.description.affiliationNorthwestern Univ, Feinberg Sch Med, Ctr Translat Metab & Hlth, Inst Publ Hlth & Med, Chicago, IL 60611 USA
dc.description.affiliationUnifespDepartment of Internal Medicine, Division of Nephrology, Universidade Federal de São Paulo (UNIFESP), Rua Pedro Toledo 282, BR-04039000 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent66-73
dc.identifierhttp://dx.doi.org/10.1159/000449260
dc.identifier.citationCardiorenal Medicine. Basel, v. 7, n. 1, p. 66-73, 2017.
dc.identifier.doi10.1159/000449260
dc.identifier.issn1664-3828
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56527
dc.identifier.wosWOS:000389244900008
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofCardiorenal Medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectVentricular arrhythmiaen
dc.subjectCardiac arrhythmiaen
dc.subjectCardiovascular diseaseen
dc.subjectChronic kidney diseaseen
dc.titleAsymptomatic Ventricular Arrhythmia and Clinical Outcomes in Chronic Kidney Disease: A Pilot Studyen
dc.typeinfo:eu-repo/semantics/article
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