Effect of Electroacupuncture on bronchial asthma induced by ovalbumin in rats

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dc.contributor.authorCarneiro, Elisabete dos Reis [UNIFESP]
dc.contributor.authorCarneiro, Celia Regina Whitaker [UNIFESP]
dc.contributor.authorCastro, Maria Alice Pereira de [UNIFESP]
dc.contributor.authorYamamura, Ysao [UNIFESP]
dc.contributor.authorSilveira, Vera Lucia Flor [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:37:39Z
dc.date.available2016-01-24T12:37:39Z
dc.date.issued2005-02-01
dc.description.abstractIntroduction: Asthma is a worldwide disabling chronic inflammatory airway disease characterized by an intense eosinophilic inflammatory infiltrate on bronchial mucous membranes. Among the complementary therapeutic approaches to asthma, acupuncture has been widely used.Objective: Here we used a rat pulmonary hypersensitivity experimental model that mimics human asthma in order to address whether electroacupuncture (EA) treatment could reduce the inflammatory process.Materials and Methods: Experimental animals were divided in four groups: control (C), immobilized (1), sham-acupuncture (SA), and acupuncture (A). All rats were sensitized with heat-solidified hen egg white implant. Using clinical acupuncture points, EA treatment began 2 days after antigen priming and was repeated on alternate days for 2 weeks. Subsequently, animals were challenged by inhalation with aggregated ovalbumin and sacrificed 24 hours later when blood samples, bronchoalveolar lavage (BAL), and lungs were collected.Results: Histopathologic analyses showed that peribronchial and perivascular inflammatory cell infiltrates were significantly lower in group A compared to groups SA and I (shown to be similar to group C). Furthermore, BAL total cell count and percentage of polymorphonuclears (as well as the differential counts of neutrophils and eosinophils) were significantly reduced in group A compared to group 1. Corsticosterone plasma levels were similar in all groups.Conclusions: Taken together these results show that EA efficiently diminishes the bronchial immune-mediated inflammation induced in rats and that this effect is dependent on the choice of specific acupoints.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol, Disiplina Neurofisiol & Fisiol Endocrine, Escola Paulista Med, BR-04023060 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, BR-04023060 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Orthoped & Traumatol, BR-04023060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol, Disiplina Neurofisiol & Fisiol Endocrine, Escola Paulista Med, BR-04023060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, BR-04023060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Orthoped & Traumatol, BR-04023060 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent127-134
dc.identifierhttps://dx.doi.org/10.1089/acm.2005.11.127
dc.identifier.citationJournal of Alternative and Complementary Medicine. Larchmont: Mary Ann Liebert Inc, v. 11, n. 1, p. 127-134, 2005.
dc.identifier.doi10.1089/acm.2005.11.127
dc.identifier.issn1075-5535
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/28147
dc.identifier.wosWOS:000227477300018
dc.language.isoeng
dc.publisherMary Ann Liebert Inc
dc.relation.ispartofJournal of Alternative and Complementary Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleEffect of Electroacupuncture on bronchial asthma induced by ovalbumin in ratsen
dc.typeinfo:eu-repo/semantics/article
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