Insulin resistance, beta-cell function, and glucose tolerance in Brazilian adolescents with obesity or risk factors for type 2 diabetes mellitus

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dc.contributor.authorQuerino da Silva, Regina Cintra
dc.contributor.authorMiranda, Walkiria Lopes
dc.contributor.authorChacra, Antonio Roberto
dc.contributor.authorDib, Sergio Atala
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:56Z
dc.date.available2016-01-24T12:41:56Z
dc.date.issued2007-03-01
dc.description.abstractObjective: To evaluate insulin resistance (IR), beta-cell function, and glucose tolerance in 119 Brazilian adolescents with obesity or risk factors (RF) for type 2 diabetes mellitus (T2DM). Study Design: We analyzed weight (kg), height (m), body mass index (BMI; kg/m(2)), waist (W; cm), acanthosis nigricans (AN), systolic and diastolic blood pressure (SBP and DBP; mm Hg), fasting plasma glucose (FPG), and 2-h plasma glucose (2hPG) on oral glucose tolerance test (OGTT; 1.75 g of glucose/weight), lipid profile [total cholesterol (TC), fractions, and triglycerides (TGs)], fasting insulin (FI) and 2-h insulin on OGTT (2hI-RIA), HOMA-B (%; beta-cell function-HOMA program), HOMA-S (%; insulin sensitivity-HOMA program) and HOMA-IR [fasting plasma insulin (mU/ml) x fasting plasma glucose (mmol/L)/22.5]. Division according to number of RF-family history of T2DM (FHT2DM), obesity, hypertension, dyslipidemia, polycystic ovary syndrome (PCOS), and AN. G1: subjects with no or one RF; G2: subjects with two or more RFs. Statistical data were nonparametrical. Results: Fasting plasma glucose (G2: 81.6 +/- 10.2 vs. G1: 79.8 +/- 9.9 mg/dl) and 2hPG (88.1 +/- 18.0 vs. 87.0 +/- 19.9 mg/dl) were not different between G2 (n = 67) and G1 (n = 52), and all adolescents had normal glucose tolerance (NGT). Fasting insulin (13.0 +/- 7.9 vs. 7.6 +/- 3.9 mu IU/ml; P < .001) and 2hI (60.2 +/- 39.1 vs. 38.3 +/- 40.0 mu IU/ml; P < .001), HOMA-B (169.1 +/- 131.6% vs. 106.1 +/- 39.9%; P < .001), and HOMA-IR (2.62 +/- 1.7 vs. 1.52 +/- 0.8; P < .001) were higher in G2. HOMA-S (92.5 +/- 59.5% vs. 152.2 +/- 100.5%; P < .001) was also lower in this lattergroup. Conclusion: Brazilian adolescents with two or more RFs for the development of T2DM have higher IR and P-cell function and lower insulin sensitivity. However, adolescents with impaired glucose tolerance (IGT) or DM have not been found, differently from similar studies. Differences in ethnic background, environment, and lifestyle factors may account for this disparity. (c) 2007 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Ctr Diabet, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Ctr Diabet, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent84-92
dc.identifierhttp://dx.doi.org/10.1016/j.jdiacomp.2005.11.006
dc.identifier.citationJournal of Diabetes and Its Complications. New York: Elsevier B.V., v. 21, n. 2, p. 84-92, 2007.
dc.identifier.doi10.1016/j.jdiacomp.2005.11.006
dc.identifier.issn1056-8727
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29552
dc.identifier.wosWOS:000244926100003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Diabetes and Its Complications
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectinsulin resistanceen
dc.subjectadolescentsen
dc.subjectBrazilianen
dc.titleInsulin resistance, beta-cell function, and glucose tolerance in Brazilian adolescents with obesity or risk factors for type 2 diabetes mellitusen
dc.typeinfo:eu-repo/semantics/article
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