Congenital Brain Abnormalities and Zika Virus: What the Radiologist Can Expect to See Prenatally and Postnatally

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dc.citation.issue1
dc.citation.volume281
dc.contributor.authorOliveira-Szejnfeld, Patricia Soares de [UNIFESP]
dc.contributor.authorLevine, Deborah
dc.contributor.authorde Oliveira Melo, Adriana Suely
dc.contributor.authorRamos Amorim, Melania Maria
dc.contributor.authorBatista, Alba Gean M.
dc.contributor.authorChimelli, Leila
dc.contributor.authorTanuri, Amilcar
dc.contributor.authorAguiar, Renato Santana
dc.contributor.authorMalinger, Gustavo
dc.contributor.authorXimenes, Renato [UNIFESP]
dc.contributor.authorRobertson, Richard
dc.contributor.authorSzejnfeld, Jacob [UNIFESP]
dc.contributor.authorTovar-Moll, Fernanda
dc.coverageOak Brook
dc.date.accessioned2020-07-31T12:47:37Z
dc.date.available2020-07-31T12:47:37Z
dc.date.issued2016
dc.description.abstractPurpose: To document the imaging findings associated with congenital Zika virus infection as found in the Instituto de Pesquisa in Campina Grande State Paraiba (IPESQ) in northeastern Brazil, where the congenital infection has been particularly severe. Materials and Methods: From June 2015 to May 2016, 438 patients were referred to the IPESQ for rash occurring during pregnancy or for suspected fetal central nervous system abnormality. Patients who underwent imaging at IPESQ were included, as well as those with documented Zika virus infection in fluid or tissue (n = 17, confirmed infection cohort) or those with brain findings suspicious for Zika virus infection, with intracranial calcifications (n = 28, presumed infection cohort). Imaging examinations included 12 fetal magnetic resonance (MR) examinations, 42 postnatal brain computed tomographic examinations, and 11 postnatal brain MR examinations. Images were reviewed by four radiologists, with final opinion achieved by means of consensus. Results: Brain abnormalities seen in confirmed (n = 17) and presumed (n = 28) congenital Zika virus infections were similar, with ventriculomegaly in 16 of 17 (94%) and 27 of 28 (96%) infections, respectivelyen
dc.description.abstractabnormalities of the corpus callosum in 16 of 17 (94%) and 22 of 28 (78%) infections, respectivelyen
dc.description.abstractand cortical migrational abnormalities in 16 of 17 (94%) and 28 of 28 (100%) infections, respectively. Although most fetuses underwent at least one examination that showed head circumference below the 5th percentile, head circumference could be normal in the presence of severe ventriculomegaly (seen in three fetuses). Intracranial calcifications were most commonly seen at the gray matter-white matter junction, in 15 of 17 (88%) and 28 of 28 (100%) confirmed and presumed infections, respectively. The basal ganglia and/or thalamus were also commonly involved with calcifications in 11 of 17 (65%) and 18 of 28 (64%) infections, respectively. The skull frequently had a collapsed appearance with overlapping sutures and redundant skin folds and, occasionally, intracranial herniation of orbital fat and clot in the confluence of sinuses. Conclusion: The spectrum of findings associated with congenital Zika virus infection in the IPESQ in northeastern Brazil is illustrated to aid the radiologist in identifying Zika virus infection at imaging. (C) RSNA, 2016en
dc.description.affiliationUniv Fed Sao Paulo, Dept Diagnost Imaging, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Diagnost Imaging, Fdn Inst Educ & Res Diagnost Imaging, Sao Paulo, Brazil
dc.description.affiliationHarvard Med Sch, Dept Radiol, Beth Israel Deaconess Med Ctr, Boston, MA USA
dc.description.affiliationInst Pesquisa Prof Amorim Neto, Campina Grande, PB, Brazil
dc.description.affiliationInst Saude Elpidio Almeida, Campina Grande, PB, Brazil
dc.description.affiliationFac Ciencias Med Campina Grande, Campina Grande, PB, Brazil
dc.description.affiliationHosp Municipal Pedro I, Serv Municipal Atendimento Transdisciplinar Gesta, Campina Grande, PB, Brazil
dc.description.affiliationUniv Fed Campina Grande, Campina Grande, PB, Brazil
dc.description.affiliationState Inst Brain, Neuropathol Lab, Rio De Janeiro, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Biol, Dept Genet, Rio De Janeiro, Brazil
dc.description.affiliationTel Aviv Univ, Sackler Fac Med, Div Ultrasound Obstet & Gynecol, Tel Aviv Sourasky Med Ctr,Lis Matern Hosp, Tel Aviv, Israel
dc.description.affiliationFetal Med Fdn Latinamerica FMFLA, Centrus Fetal Med, Campinas, SP, Brazil
dc.description.affiliationBoston Childrens Hosp, Boston, MA USA
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Biomed Sci, Rio De Janeiro, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Natl Ctr Struct Biol & Bioimaging, Rio De Janeiro, Brazil
dc.description.affiliationDOr Inst Res & Educ, Rua Diniz Cordeiro 30, BR-22881100 Rio De Janeiro, RJ, Brazil
dc.description.affiliationUnifespDept of Diagnostic Imaging, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.affiliationUnifespFoundation Inst for Education and Research in Diagnostic Imaging, Dept of Diagnostic Imaging, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent203-218
dc.identifierhttp://dx.doi.org/10.1148/radiol.2016161584
dc.identifier.citationRadiology. Oak Brook, v. 281, n. 1, p. 203-218, 2016.
dc.identifier.doi10.1148/radiol.2016161584
dc.identifier.issn0033-8419
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56948
dc.identifier.wosWOS:000391313600023
dc.language.isoeng
dc.publisherRadiological Soc North America
dc.relation.ispartofRadiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleCongenital Brain Abnormalities and Zika Virus: What the Radiologist Can Expect to See Prenatally and Postnatallyen
dc.typeinfo:eu-repo/semantics/article
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