Antihypertensive efficacy of amlodipine and losartan after two 'missed' doses in patients with mild to moderate essential hypertension

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dc.contributor.authorRibeiro, Artur Beltrame [UNIFESP]
dc.contributor.authorMion Junior, Decio
dc.contributor.authorMarin, M. J.
dc.contributor.authorMajul, Claudio
dc.contributor.authorBotero, R.
dc.contributor.authorLopez, N. R.
dc.contributor.authorGonzalez, S.
dc.contributor.authorIzurieta, H.
dc.contributor.authorFrancischetti, Emilio Antonio
dc.contributor.authorLatin Amer Hypertension Study Grp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionPoliclin Bancario
dc.contributor.institutionHosp Santojanni
dc.contributor.institutionClin Medellin
dc.contributor.institutionCtr Med Docente La Trinidad
dc.contributor.institutionGen Hosp Durango
dc.contributor.institutionCtr Med Alemania
dc.contributor.institutionRio de Janeiro Sch Med
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-06-15T18:02:33Z
dc.date.available2018-06-15T18:02:33Z
dc.date.issued2007-11-01
dc.description.abstractWe compared the effects of amlodipine (5 - 10 mg, n = 94) and losartan (50 100 mg, n = 94) on the lowering of blood pressure (BP) at steady state and after two missed doses, as well as on tolerability. This was a randomized, double-blind study of 12 weeks of active treatment followed by 2 days of placebo treatment. Twenty-four-hour ambulatory blood pressure monitoring and office BP measurements were performed at baseline, week 12 and after the 2-day drug holiday. After 12 weeks, amlodipine was significantly more effective than losartan in reducing both 24-h systolic blood pressure (SBP) (-18.0 versus -10.8 mmHg) and diastolic blood pressure (DBP) (-10.6 versus -8.0 mmHg). While mean SBP and DBP for both treatments increased comparably during the drug holiday, BP values remained significantly lower than baseline for both treatments. The superior BP-lowering effect of amlodipine compared with losartan was maintained during the drug holiday.en
dc.description.affiliationHosp Rim & Hipertensao, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationPoliclin Bancario, Div Cardiol, Ctr Hipertens Arterial, Ciudad de Buenos Aires, Argentina
dc.description.affiliationHosp Santojanni, Serv Cardiol, Ciudad de Buenos Aires, Argentina
dc.description.affiliationClin Medellin, Medellin, Colombia
dc.description.affiliationCtr Med Docente La Trinidad, Caracas, Venezuela
dc.description.affiliationGen Hosp Durango, Durango, Mexico
dc.description.affiliationCtr Med Alemania, Quito, Ecuador
dc.description.affiliationRio de Janeiro Sch Med, Rio De Janeiro, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Sao Paulo, Brazil
dc.description.affiliationUnifespHosp Rim & Hipertensao, Escola Paulista Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent762-772
dc.identifierhttps://dx.doi.org/10.1177/147323000703500604
dc.identifier.citationJournal Of International Medical Research. Worthing: Field House Publishing Llp, v. 35, n. 6, p. 762-772, 2007.
dc.identifier.doi10.1177/147323000703500604
dc.identifier.issn0300-0605
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/44438
dc.identifier.wosWOS:000251382700004
dc.language.isoeng
dc.publisherField House Publishing Llp
dc.relation.ispartofJournal Of International Medical Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAmlodipineen
dc.subjectLosartanen
dc.subjectAntihypertensive drugsen
dc.subjectHypertensionen
dc.subjectAmbulatory blood pressure monitoringen
dc.subjectDrug holidayen
dc.subjectTherapeutic coverageen
dc.titleAntihypertensive efficacy of amlodipine and losartan after two 'missed' doses in patients with mild to moderate essential hypertensionen
dc.typeinfo:eu-repo/semantics/article
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