A double-dissociation of behavioural and event-related potential effects of two benzodiazepines with similar potencies

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dc.contributor.authorPompeia, S.
dc.contributor.authorBueno, OFA
dc.contributor.authorLucchesi, L. M.
dc.contributor.authorManzano, G. M.
dc.contributor.authorGalduroz, JCF
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T18:11:02Z
dc.date.available2018-06-15T18:11:02Z
dc.date.issued2000-09-01
dc.description.abstractThis study was designed to explore the role of benzodiazepine affinity to benzodiazepine binding site on acute psychomotor, subjective and memory effects, as well as auditory Event Related Potential (ERP) latencies, in healthy volunteers. Two benzodiazepines with similar affinity to benzodiazepine binding sites, or potency, were compared: the atypical compound lorazepam (2.0 mg), which has been reported to impair priming, and a standard benzodiazepine, flunitrazepam (0.6 mg, 0.8 mg, 1.0 mg). The study followed a placebo-controlled, double-blind, parallel-group design. Sixty subjects completed a test battery before treatment and at theoretical peak plasma concentration of drugs. Lorazepam and 1.0 mg of flunitrazepam led to comparable alterations on psychomotor, subjective and auditory episodic memory measures. A double-dissociation was found for lorazepam and the equipotent dose of flunitrazepam (1.0 mg): lorazepam was more deleterious than flunitrazepam in time taken to identify fragmented shapes. Lorazepam also impaired direct and indirect stem-completion in comparison to placebo, but this effect was abolished when time to identify shapes was used as a covariate. By contrast, 1.0 mg of flunitrazepam prolonged auditory ERP latencies to a greater extent than lorazepam. High affinity to the benzodiazepine binding sites does not seem to explain the consistent lorazepam-induced impairment of indirect stem-completion. Differences in impairment profile between the benzodiazepines employed may relate to the modality (visual or not) of the tasks used.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psicobiol, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationUNIFESP, Dept Neurol, Setor Neurofisiol Clin, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psicobiol, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationUnifespUNIFESP, Dept Neurol, Setor Neurofisiol Clin, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent288-298
dc.identifierhttp://dx.doi.org/10.1177/026988110001400318
dc.identifier.citationJournal Of Psychopharmacology. London: Sage Publications Ltd, v. 14, n. 3, p. 288-298, 2000.
dc.identifier.doi10.1177/026988110001400318
dc.identifier.issn0269-8811
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44603
dc.identifier.wosWOS:000165317500017
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.ispartofJournal Of Psychopharmacology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dc.subjectbenzodiazepinesen
dc.subjectevent-related potentialsen
dc.subjectflunitrazepamen
dc.subjectlorazepamen
dc.subjectmemoryen
dc.subjectpotencyen
dc.subjectpsychomotor performanceen
dc.titleA double-dissociation of behavioural and event-related potential effects of two benzodiazepines with similar potenciesen
dc.typeinfo:eu-repo/semantics/article
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