Effects of zolpidem on sedation, anxiety, and memory in the plus-maze discriminative avoidance task

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dc.contributor.authorZanin, Karina A. [UNIFESP]
dc.contributor.authorPatti, Camilla L. [UNIFESP]
dc.contributor.authorSanday, Leandro [UNIFESP]
dc.contributor.authorFernandes-Santos, Luciano [UNIFESP]
dc.contributor.authorOliveira, Larissa C. [UNIFESP]
dc.contributor.authorPoyares, Dalva [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorFrussa-Filho, Roberto [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:31:29Z
dc.date.available2016-01-24T14:31:29Z
dc.date.issued2013-04-01
dc.description.abstractZolpidem (Zolp), a hypnotic drug prescribed to treat insomnia, may have negative effects on memory, but reports are inconsistent.We examined the effects of acute doses of Zolp (2, 5, or 10 mg/kg, i.p.) on memory formation (learning, consolidation, and retrieval) using the plus-maze discriminative avoidance task.Mice were acutely treated with Zolp 30 min before training or testing. in addition, the effects of Zolp and midazolam (Mid; a classic benzodiazepine) on consolidation at different time points were examined. the possible role of state dependency was investigated using combined pre-training and pre-test treatments.Zolp produced a dose-dependent sedative effect, without modifying anxiety-like behavior. the pre-training administration of 5 or 10 mg/kg resulted in retention deficits. When administered immediately after training or before testing, memory was preserved. Zolp post-training administration (2 or 3 h) impaired subsequent memory. There was no participation of state dependency phenomenon in the amnestic effects of Zolp. Similar to Zolp, Mid impaired memory consolidation when administered 1 h after training.Amnestic effects occurred when Zolp was administered either before or 2-3 h after training. These memory deficits are not related to state dependency. Moreover, Zolp did not impair memory retrieval. Notably, the memory-impairing effects of Zolp are similar to those of Mid, with the exception of the time point at which the drug can modify consolidation. Finally, the memory effects were unrelated to sedation or anxiolysis.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipIDFAPESP: 1998/14303-3
dc.description.sponsorshipIDFAPESP: 2008/08823-8
dc.description.sponsorshipIDFAPESP: 2009/00465-8
dc.format.extent459-474
dc.identifierhttp://dx.doi.org/10.1007/s00213-012-2756-3
dc.identifier.citationPsychopharmacology. New York: Springer, v. 226, n. 3, p. 459-474, 2013.
dc.identifier.doi10.1007/s00213-012-2756-3
dc.identifier.issn0033-3158
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36139
dc.identifier.wosWOS:000316085800002
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofPsychopharmacology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectZolpidemen
dc.subjectMemoryen
dc.subjectConsolidationen
dc.subjectState dependencyen
dc.subjectPlus-maze discriminative avoidance tasken
dc.subjectPM-DATen
dc.titleEffects of zolpidem on sedation, anxiety, and memory in the plus-maze discriminative avoidance tasken
dc.typeinfo:eu-repo/semantics/article
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