Granular cell dispersion and bilamination: two distinct and bilamination, histopathological patterns in epileptic hippocampi?

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dc.contributor.authorSilva, Alexandre Valotta da [UNIFESP]
dc.contributor.authorHouzel, Jean-Christophe
dc.contributor.authorCroaro, Ingrid [UNIFESP]|Yacubian, Elza Márcia Targas [UNIFESP]
dc.contributor.authorStávale, João Norberto [UNIFESP]
dc.contributor.authorCenteno, Ricardo Silva [UNIFESP]
dc.contributor.authorCavalheiro, Esper Abrão [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.date.accessioned2018-06-15T17:17:32Z
dc.date.available2018-06-15T17:17:32Z
dc.date.issued2007-12-01
dc.description.abstractCytoarchitectural modifications of the dentate gyrus are among the most obvious abnormalities observed in the hippocampal sclerosis associated with refractory epilepsy. Here, we examined the morphological changes of granular cells (dispersion, bilamination and cell loss) in sclerotic hippocampi from nine TLE patients, comparing abnormal and preserved areas. A total of 2 577 granular cells were analyzed with respect to four different histopathological patterns: areas with bilamination (n = 936), areas with dispersion (n = 905), areas with neuronal loss (n = 279), and preserved areas (n = 457). Quantitative parameters included somatic perimeter (P), area (A) and form factor (ff).Although different patterns were often observed in the same patient, highly significant differences were observed (p < 0.0001) when patterns were compared to one another. Since granular cell dispersion and bilamination have different morphological aspects in sclerotic hippocampi from TLE patients, we suggest that these patterns should be considered separately. Future studies are needed to determine the frequency with which these patterns occur in the general population and whether each one can interfere with seizure susceptibility.en
dc.description.affiliationUniv Fed Sao Paulo, Lab Neurol Expt, UNIFESP EPM, Dept Ciencias Saude, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Dept Anat ICB, Rio De Janeiro, Brazil
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP EPM, Dept Patol, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP EPM, Dept Neurol & Neurocirur, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Lab Neurol Expt, UNIFESP EPM, Dept Ciencias Saude, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP EPM, Dept Patol, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP EPM, Dept Neurol & Neurocirur, BR-04023900 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent438-442
dc.identifierhttp://www.jle.com/en/revues/epd/e-docs/granular_cell_dispersion_and_bilamination_two_distinct_histopathological_patterns_in_epileptic_hippocampi__276425/article.phtml
dc.identifier.citationEpileptic Disorders. Montrouge: John Libbey Eurotext Ltd, v. 9, n. 4, p. 438-442, 2007.
dc.identifier.issn1294-9361
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43571
dc.identifier.wosWOS:000252669900007
dc.language.isoeng
dc.publisherJohn Libbey Eurotext Ltd
dc.relation.ispartofEpileptic Disorders
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthippocampal sclerosisen
dc.subjectrefractory epilepsyen
dc.subjectimmunocytochemistryen
dc.subjectmorphometryen
dc.subjecttemporal lobeen
dc.titleGranular cell dispersion and bilamination: two distinct and bilamination, histopathological patterns in epileptic hippocampi?en
dc.typeinfo:eu-repo/semantics/article
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