MK-801 blocks the development of behavioral sensitization to ethanol

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dc.contributor.authorCamarini, R.
dc.contributor.authorFrussa, R.
dc.contributor.authorMonteiro, M. G.
dc.contributor.authorCalil, H. M.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:31:02Z
dc.date.available2016-01-24T12:31:02Z
dc.date.issued2000-03-01
dc.description.abstractBackground: Studies have indicated that MK-801 (a noncompetitive N-methyl-D-aspartate receptor antagonist) participates in the long-term neural changes responsible for sensitization to stimulant drugs. It is known that repeated administration of low doses of ethanol sensitizes animals to its stimulant effect. in this work we investigated whether MK-801 alters the development of behavioral sensitization to ethanol.Methods: Groups of male Swiss mice were treated with saline or ethanol (2.0 g/kg) plus saline or MK-801 (0.25 mg/kg) for 21 days. On day 25, all animals received an ethanol challenge injection (2.0 g/kg). We measured locomotor activity on days 1, 7, 14, 21 and 25. in addition, we assessed the effects of different doses of MK-801 on the response to a low dose of ethanol (2.0 g/kg).Results: Ethanol-treated mice developed sensitization to the locomotor-stimulating effect of the drug, whereas those concomitantly receiving ethanol and MK-801 did nut. All doses of MK-801 that were used stimulated the locomotor activity of both ethanol and saline-treated animals.Conclusions: the findings support the hypothesis that N-methyl-D-aspartate receptors have an important role in the development of sensitization to drugs of abuse.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pharmacol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pharmacol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent285-290
dc.identifierhttp://dx.doi.org/10.1097/00000374-200003000-00005
dc.identifier.citationAlcoholism-clinical and Experimental Research. Philadelphia: Lippincott Williams & Wilkins, v. 24, n. 3, p. 285-290, 2000.
dc.identifier.doi10.1097/00000374-200003000-00005
dc.identifier.issn0145-6008
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26265
dc.identifier.wosWOS:000086128000006
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofAlcoholism-clinical and Experimental Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectethanolen
dc.subjectsensitizationen
dc.subjectMK-801en
dc.subjectN-methyl-D-aspartateen
dc.subjectmiceen
dc.titleMK-801 blocks the development of behavioral sensitization to ethanolen
dc.typeinfo:eu-repo/semantics/article
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