REM sleep deprivation impairs muscle regeneration in rats

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dc.citation.issue1
dc.citation.volume35
dc.contributor.authorMônico-Neto, Marcos [UNIFESP]
dc.contributor.authorDattilo, Murilo [UNIFESP]
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.authorLee, Kil Sun [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorAntunes, Hanna Karen Moreira [UNIFESP]
dc.coverageAbingdon
dc.date.accessioned2020-07-31T12:46:33Z
dc.date.available2020-07-31T12:46:33Z
dc.date.issued2017
dc.description.abstractIntroduction: The aim was observe the influence of sleep deprivation (SD) and sleep recovery on muscle regeneration process in rats submitted to cryolesion. Methods: Thirty-two Wistar rats were randomly allocated in four groups: control (CTL), SD for 96 h (SD96), control plus sleep recovery period (CTL + R) and SD96h plus 96 h of sleep recovery (SD96 + R). The animals were submitted to muscle injury by cryolesioning, after to SD and sleep recovery. Results: The major outcomes of this study were the reduction of muscular IGF-1 in both legs (injured and uninjured) and a delay in muscle regeneration process of animals submitted to SD compared to animals that slept, with increase connective tissue, inflammatory infiltrate and minor muscle fibers. Conclusions: SD impairs muscle regeneration in rats, moreover reduces muscular IGF-1 and sleep recovery was able to restore it to basal levels, but it was not enough to normalize the muscle regeneration.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biosci, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biochem, Sao Paulo, Brazil
dc.description.affiliationLab Interdisciplinar Fisiol & Exercicio LAIFE, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Sch Phys Educ Physiotherapy & Occupat Therapy, Belo Horizonte, MG, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, Sao Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biochem, Sao Paulo, Brazil
dc.description.affiliationUnifespLab Interdisciplinar Fisiol & Exercicio LAIFE, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCentros de Pesquisa, Inovação e Difusão (CEPID)/SONO/FAPESP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 2009/11056-1
dc.description.sponsorshipIDFAPESP: 2011/15962-7
dc.description.sponsorshipIDFAPESP: 2013/00152-5
dc.description.sponsorshipIDCEPID/SONO-FAPESP: 98/14303-3
dc.format.extent12-18
dc.identifierhttp://dx.doi.org/10.1080/08977194.2017.1314277
dc.identifier.citationGrowth Factors. Abingdon, v. 35, n. 1, p. 12-18, 2017.
dc.identifier.doi10.1080/08977194.2017.1314277
dc.identifier.issn0897-7194
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56271
dc.identifier.wosWOS:000403938000002
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofGrowth Factors
dc.rightsAcesso restrito
dc.subjectIGF-1en
dc.subjectsleep lossen
dc.subjectskeletal muscleen
dc.subjectmuscle recoveryen
dc.titleREM sleep deprivation impairs muscle regeneration in ratsen
dc.typeArtigo
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