Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis

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dc.citation.volume18
dc.contributor.authorCristelli, M. P. [UNIFESP]
dc.contributor.authorCofan, F.
dc.contributor.authorRico, N.
dc.contributor.authorTrullas, J. C.
dc.contributor.authorManzardo, C.
dc.contributor.authorAguero, F.
dc.contributor.authorBedini, J. L.
dc.contributor.authorMoreno, A.
dc.contributor.authorOppenheimer, F.
dc.contributor.authorMiro, J. M.
dc.coverageLondon
dc.date.accessioned2020-07-17T14:02:58Z
dc.date.available2020-07-17T14:02:58Z
dc.date.issued2017
dc.description.abstractBackground: Accurately determining renal function is essential for clinical management of HIV patients. Classically, it has been evaluated by estimating glomerular filtration rate (eGFR) with the MDRD-equation, but today there is evidence that the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation has greater diagnostic accuracy. To date, however, little information exists on patients with HIV-infection. This study aimed to evaluate eGFR by CKD-EPI vs. MDRD equations and to stratify renal function according to KDIGO guidelines. Methods: Cross-sectional, single center study including adult patients with HIV-infection. Results: Four thousand five hundred three patients with HIV-infection (864 womenen
dc.description.abstract19%) were examined. Median age was 45 years (IQR 37-52), and median baseline creatinine was 0.93 mg/dL (IQR 0.82-1.05). A similar distribution of absolute measures of eGFR was found using both formulas (p = 0.548). Baseline median eGFR was 95.2 and 90.4 mL/min/ 1.73 m(2) for CKD-EPI and MDRD equations (p < 0.001), respectively. Of the 4503 measurements, 4109 (91.2%) agreed, with a kappa index of 0.803. MDRD classified 7.3% of patients as '' mild reduced GFR '' who were classified as '' normal function '' with CKD-EPI. Using CKD-EPI, it was possible to identify '' normal function '' (>90 mL/min/1.73 m(2)) in 73% patients and '' mild reduced GFR '' (60-89 mL/min/1.73 m(2)) in 24.3% of the patients, formerly classified as >60 mL/min/1.73 m(2) with MDRD. Conclusions: There was good correlation between CKD-EPI and MDRD. Estimating renal function using CKD-EPI equation allowed better staging of renal function and should be considered the method of choice. CKD-EPI identified a significant proportion of patients (24%) with mild reduced GFR (60-89 mL/min/1.73 m(2)).en
dc.description.affiliationUniv Fed Sao Paulo, Kidney Transplant Div, Hosp Rim, Sao Paulo, Brazil
dc.description.affiliationUniv Barcelona, Hosp Clin IDIBAPS, Nephrol & Renal Transplantat Serv, Barcelona, Spain
dc.description.affiliationHosp Clin Barcelona, Biomed Diag Ctr, Core Lab, Barcelona, Spain
dc.description.affiliationHosp Olot, Internal Med Serv, Girona, Spain
dc.description.affiliationUniv Girona, Dept Med Sci, Girona, Spain
dc.description.affiliationUniv Barcelona, Hosp Clin IDIBAPS, Infect Dis Serv, Barcelona, Spain
dc.description.affiliationUnifespUniv Fed Sao Paulo, Kidney Transplant Div, Hosp Rim, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipRed de Sida
dc.description.sponsorshipInstituto de Salud Carlos III, Madrid, Spain
dc.description.sponsorshipEuropean Regional Development Fund (ERDF)
dc.description.sponsorshipIDRed de Sida: RD12/0017/0001
dc.description.sponsorshipIDInstituto de Salud Carlos III, Madrid, Spain: INT15/00168
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1186/s12882-017-0470-4
dc.identifier.citationBmc Nephrology. London, v. 18, p. -, 2017.
dc.identifier.doi10.1186/s12882-017-0470-4
dc.identifier.fileWOS000397680500002.pdf
dc.identifier.issn1471-2369
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55105
dc.identifier.wosWOS:000397680500002
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofBmc Nephrology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHIV-infectionen
dc.subjectChronic kidney diseaseen
dc.subjectGlomerular filtration rate estimatesen
dc.titleEstimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysisen
dc.typeinfo:eu-repo/semantics/article
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