Inhibitory effects of modafinil on emotional memory in mice

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dc.contributor.authorFernandes, Helaine A. [UNIFESP]
dc.contributor.authorZanin, Karina A. [UNIFESP]
dc.contributor.authorPatti, Camilla L. [UNIFESP]
dc.contributor.authorWuo-Silva, Raphael [UNIFESP]
dc.contributor.authorCarvalho, Rita C. [UNIFESP]
dc.contributor.authorFernandes-Santos, Luciano [UNIFESP]
dc.contributor.authorBittencourt, Lia R. A. [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorFrussa-Filho, Roberto [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:31:03Z
dc.date.available2016-01-24T14:31:03Z
dc.date.issued2013-01-01
dc.description.abstractModafinil (MOD), a psychostimulant used to treat narcolepsy, excessive daytime sleepiness, and sleepiness due to obstructive sleep apnea, appears to promote a possible facilitatory effect on cognitive function. in the present study, we investigated the effects of the acute administration of MOD on the different steps of emotional memory formation and usage (acquisition, consolidation and retrieval) as well as the possible participation of the state-dependency phenomenon on the cognitive effects of this compound. Mice were acutely treated with 32, 64 or 128 mg/kg MOD before training or testing or immediately after training and were subjected to the plus-maze discriminative avoidance task. the results showed that although pre-training MOD administration did not exert any effects on learning, the doses of 32 or 64 mg/kg induced emotional memory deficits during testing. Still, the post-training acute administration of the higher doses of MOD (64 and 128 mg/kg) impaired associative memory consolidation. When the drug was administered pre-test, only the 32 mg/kg dose impaired the task retrieval. Importantly, the cognitive impairing effects induced by 32 mg/kg MOD were not related to the phenomenon of state-dependency. in all, our findings provide pre-clinical evidence of potential emotional memory amnesia induced by MOD.This article is part of a Special Issue entitled 'Cognitive Enhancers'. (C) 2012 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipIDFAPESP: 1998/14303-3
dc.format.extent365-370
dc.identifierhttp://dx.doi.org/10.1016/j.neuropharm.2012.06.058
dc.identifier.citationNeuropharmacology. Oxford: Pergamon-Elsevier B.V., v. 64, p. 365-370, 2013.
dc.identifier.doi10.1016/j.neuropharm.2012.06.058
dc.identifier.issn0028-3908
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35809
dc.identifier.wosWOS:000311250300041
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuropharmacology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectModafinilen
dc.subjectLearningen
dc.subjectConsolidationen
dc.subjectRetrievalen
dc.subjectState-dependencyen
dc.subjectPlus-maze discriminative avoidance tasken
dc.titleInhibitory effects of modafinil on emotional memory in miceen
dc.typeinfo:eu-repo/semantics/article
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