Prophylactic Supplementation of Bifidobacterium longum 5(1A) Protects Mice from Ovariectomy-Induced Exacerbated Allergic Airway Inflammation and Airway Hyperresponsiveness

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dc.citation.volume8
dc.contributor.authorMendes, Eduardo [UNIFESP]
dc.contributor.authorAcetturi, Beatriz G.
dc.contributor.authorThomas, Andrew M.
dc.contributor.authorMartins, Flaviano dos S.
dc.contributor.authorCrisma, Amanda R.
dc.contributor.authorMurata, Gilson
dc.contributor.authorBraga, TarcioT
dc.contributor.authorCamara, Niels O. S.
dc.contributor.authorFranco, Adriana L. dos S.
dc.contributor.authorSetubal, Joao C.
dc.contributor.authorRibeiro, Willian R. [UNIFESP]
dc.contributor.authorValduga, Claudete J.
dc.contributor.authorCuri, Rui
dc.contributor.authorDias-Neto, Emmanuel
dc.contributor.authorTavares-de-Lima, Wothan
dc.contributor.authorFerreira, Caroline M. [UNIFESP]
dc.coverageLausanne
dc.date.accessioned2020-08-04T13:40:12Z
dc.date.available2020-08-04T13:40:12Z
dc.date.issued2017
dc.description.abstractAsthma is a chronic inflammatory disease that affects more females than males after puberty, and its symptoms and severity in women change during menstruation and menopause. Recently, evidence has demonstrated that interactions among the microbiota, female sex hormones, and immunity are associated with the development of autoimmune diseases. However, no studies have investigated if therapeutic gut microbiota modulation strategies could affect asthma exacerbation during menstruation and menopause. Here we aimed to examine the preventive effects of a probiotic, Bifidobacterium longum 5(1A), on airway inflammation exacerbation in allergic ovariectomized mice. We first evaluated the gut microbiota composition and diversity in mice 10 days after ovariectomy. Next, we examined whether re-exposure of ovariectomized allergic mice to antigen (ovalbumin) would lead to exacerbation of lung inflammation. Finally, we evaluated the preventive and treatment effect of B. longum 5(1A) on lung inflammation and airway hyperresponsiveness. Our results showed that whereas ovariectomy caused no alterations in the gut microbiota composition and diversity in this animal model, 10 days after ovariectomy, preventive use administration of B. longum 5(1A), rather than its use after surgery was capable of attenuate the exacerbated lung inflammation and hyperresponsiveness in ovariectomized allergic mice. This prophylactic effect of B. longum 5(1A) involves acetate production, which led to increased fecal acetate levels and, consequently, increased Treg cells in ovariectomized allergic mice.en
dc.description.affiliationUniv Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, Diadema, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci 1, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationCIPE, AC Camargo Canc Ctr, Med Genom Lab, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Bioinformat Grad Program, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Inst Biol Sci, Dept Microbiol, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci 4, Dept Immunol, Sao Paulo, Brazil
dc.description.affiliationUniv Nove Julho, Post Grad Program Biophoton Appl Hlth Sci, Sao Paulo, Brazil
dc.description.affiliationUniv Anhanguera Sao Paulo, Dept Pharm & Biotechnol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Med Sch, Inst Psychiat, Lab Neurosci LIM 27, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, Diadema, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.description.sponsorshipCNPq (The National Council for Scientific and Technological Development)
dc.description.sponsorshipIDFAPESP: 2012/50410-8
dc.description.sponsorshipIDCNPq: 486037/2012-6
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fmicb.2017.01732
dc.identifier.citationFrontiers In Microbiology. Lausanne, v. 8, p. -, 2017.
dc.identifier.doi10.3389/fmicb.2017.01732
dc.identifier.fileWOS000410028800001.pdf
dc.identifier.issn1664-302X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57367
dc.identifier.wosWOS:000410028800001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Microbiology
dc.rightsAcesso aberto
dc.subjectprobioticen
dc.subjectBifidobacterium longumen
dc.subjectairway inflammationen
dc.subjectovariectomyen
dc.subjectmicrobiotaen
dc.titleProphylactic Supplementation of Bifidobacterium longum 5(1A) Protects Mice from Ovariectomy-Induced Exacerbated Allergic Airway Inflammation and Airway Hyperresponsivenessen
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