Aerobic exercise reduces hippocampal ERK and p38 activation and improves memory of middle-aged rats

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dc.contributor.authorCardoso, Fabrizio dos Santos
dc.contributor.authorFranca, Erivelton Fernandes
dc.contributor.authorSerra, Fernando Tadeu
dc.contributor.authorVictorino, Angelica Begatti [UNIFESP]
dc.contributor.authorde Almeida, Alexandre Aparecido [UNIFESP]
dc.contributor.authorFernandes, Jansen [UNIFESP]
dc.contributor.authorCabral, Francisco Romero
dc.contributor.authorVenancio, Daniel Paulino
dc.contributor.authorArida, Ricardo Mario [UNIFESP]
dc.contributor.authorda Silva, Sergio Gomes
dc.date.accessioned2019-08-19T11:50:15Z
dc.date.available2019-08-19T11:50:15Z
dc.date.issued2017
dc.description.abstractAging is often accompanied by cognitive decline, memory impairment, and an increased susceptibility to neurodegenerative disorders. Although the physiological processes of aging are not fully understood, these age-related changes have been interpreted by means of various cellular and molecular theories. Among these theories, alterations in the intracellular signaling pathways associated with cell growth, proliferation, and survival have been highlighted. Based on these observations and on recent evidence showing the beneficial effects of exercise on cognitive function in the elderly, we investigated the cell signaling pathways in the hippocampal formation of middle-aged rats (18months old) submitted to treadmill exercise over 10 days. To do this, we evaluated the hippocampal activation of intracellular signaling proteins linked to cell growth, proliferation, and survival, such as Akt, mTOR, p70S6K, ERK, CREB, and p38. We also explored the cognitive performance (inhibitory avoidance) of middle-aged rats. It was found that physical exercise reduces ERK and p38 activation in the hippocampal formation of aged rats, when compared to the control group. The hippocampal activation and expression of Akt, mTOR, p70S6K, and CREB were not statistically different between the groups. It was also observed that aged rats from the exercise group exhibited better cognitive performance in the inhibitory avoidance task (aversive memory) than aged rats from the control group. Our results indicate that physical exercise reduces intracellular signaling pathways linked to inflammation and cell death (i.e., ERK and p38) and improves memory in middle-aged rats.en
dc.description.affiliationUniv Mogi Das Cruzes UMC, Mogi Das Cruzes, SP, Brazil
dc.description.affiliationUniv Fed São Paulo UNIFESP, São Paulo, SP, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, São Paulo, SP, Brazil
dc.description.affiliationABC, Fac Med, Dept Morfol & Fisiol, Santo Andre, SP, Brazil
dc.description.affiliationUnifespUniv Fed São Paulo UNIFESP, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo ao Ensino e Pesquisa (FAEP)
dc.description.sponsorshipFundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 14/00035-1
dc.format.extent899-905
dc.identifierhttp://dx.doi.org/10.1002/hipo.22740
dc.identifier.citationHippocampus. Hoboken, v. 27, n. 8, p. 899-905, 2017.
dc.identifier.doi10.1002/hipo.22740
dc.identifier.issn1050-9631
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51499
dc.identifier.wosWOS:000405552500007
dc.language.isoeng
dc.publisherWiley
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectagingen
dc.subjectbrainen
dc.subjecthippocampusen
dc.subjectp38en
dc.subjectphysical exerciseen
dc.titleAerobic exercise reduces hippocampal ERK and p38 activation and improves memory of middle-aged ratsen
dc.typeinfo:eu-repo/semantics/article
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