Characterising subtypes of hippocampal sclerosis and reorganization: correlation with pre and postoperative memory deficit

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dc.citation.issue2
dc.citation.volumev. 28
dc.contributor.authorJardim, Anaclara Prada [UNIFESP]
dc.contributor.authorLiu, Joan
dc.contributor.authorBaber, Jack
dc.contributor.authorMichalak, Zuzanna
dc.contributor.authorReeves, Cheryl
dc.contributor.authorEllis, Matthew
dc.contributor.authorNovy, Jan
dc.contributor.authorde Tisi, Jane
dc.contributor.authorMcEvoy, Andrew
dc.contributor.authorMiserocchi, Anna
dc.contributor.authorYacubian, Elza Marcia Targas [UNIFESP]
dc.contributor.authorSisodiya, Sanjay
dc.contributor.authorThompson, Pamela
dc.contributor.authorThom, Maria
dc.coverageHoboken
dc.date.accessioned2020-07-20T16:31:22Z
dc.date.available2020-07-20T16:31:22Z
dc.date.issued2018
dc.description.abstractNeuropathological subtypes of hippocampal sclerosis (HS) in temporal lobe epilepsy (The2013 International League Against Epilepsy classification) are based on the qualitativeassessment of patterns of neuronal loss with NeuN. In practice, some cases appear indeterminate between type 1 (CA1 and CA4 loss) and type 2 HS (CA1 loss) and we predicted that MAP2 would enable a more stringent classification. HS subtypes, as well asthe accompanying alteration of axonal networks, regenerative capacity and neurodegeneration have been previously correlated with outcome and memory deficits and may provide prognostic clinical information. We selected 92 cases: 52 type 1 HS, 15 type 2 HS, 18 indeterminate-HS and 7 no-HS. Quantitative analysis was carried out on NeuN and MAP2 stained sections and a labeling index (LI) calculated for six hippocampal subfields. We also evaluated hippocampal regenerative activity (MCM2, nestin, olig2, calbindin), degeneration (AT8/phosphorylated tau) and mossy-fiber pathway re-organization (ZnT3). Pathology measures were correlated with clinical epilepsy history, memory and naming test scores and postoperative outcomes, at 1 year following surgery. MAP2 LI in indeterminate-HS was statistically similar to type 2 HS but this clustering was not shown with NeuN. Moderate verbal and visual memory deficits were noted in all HS types, including 54% and 69% of type 2 HS. Memory deficits correlated with several pathology factors including lower NeuN or MAP2 LI in CA4, CA1, dentate gyrus (DG) and subiculum and poor preservation of the mossy fiber pathway. Decline in memory at 1 year associated with AT8 labeling in the subiculum and DG but not HS type. We conclude that MAP2 is a helpful addition in the classification of HS in some cases. Classification of HS subtype, however, did not significantly correlate with outcome or pre- or postoperative memory dysfunction, which was associated with multiple pathology factors including hippocampal axonal pathways, regenerative capacity and degenerative changes.en
dc.description.affiliationUCL Inst Neurol, Dept Clin & Expt Epilepsy, London WCN 1BG, England
dc.description.affiliationUniv Fed Sao Paulo, Dept Neurol & Neurosurg, UNIFESP, Sao Paulo, Brazil
dc.description.affiliationNatl Hosp Neurol & Neurosurg, Dept Neuropathol, Queen Sq, London WCN 1BG, England
dc.description.affiliationNatl Hosp Neurol & Neurosurg, Dept Neurol, Queen Sq, London WCN 1BG, England
dc.description.affiliationUniv Lausanne, CHUV, Dept Neurosci Clin, Serv Neurol, Lausanne, Switzerland
dc.description.affiliationNatl Hosp Neurol & Neurosurg, Dept Neurosurg, Queen Sq, London WCN 1BG, England
dc.description.affiliationNatl Hosp Neurol & Neurosurg, Dept Neuropsychol, Queen Sq, London WCN 1BG, England
dc.description.affiliationEpilepsy Soc Res Ctr, Epilepsy Soc, Gerrards Cross SL9 0RJ, Bucks, England
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Neurol & Neurosurg, UNIFESP, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipEuropean Union
dc.description.sponsorshipCNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
dc.description.sponsorshipMedical Research Council
dc.description.sponsorshipDepartment of Health's NIHR Biomedical Research Centres funding scheme
dc.description.sponsorshipEpilepsy Society
dc.description.sponsorshipIDEU: 602102
dc.description.sponsorshipIDMRC: MR/JO127OX/1
dc.format.extent143-154
dc.identifierhttp://dx.doi.org/10.1111/bpa.12514
dc.identifier.citationBrain Pathology. Hoboken, v. 28, n. 2, p. 143-154, 2018.
dc.identifier.doi10.1111/bpa.12514
dc.identifier.fileWOS000426841200001.pdf
dc.identifier.issn1015-6305
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55922
dc.identifier.wosWOS:000426841200001
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofBrain Pathology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthippocampal sclerosisen
dc.subjectmemoryen
dc.subjectmossy fiber sproutingen
dc.subjecttemporal lobe epilepsyen
dc.titleCharacterising subtypes of hippocampal sclerosis and reorganization: correlation with pre and postoperative memory deficiten
dc.typeinfo:eu-repo/semantics/article
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