Effects of the Adenosine Deaminase Polymorphism and Caffeine Intake on Sleep Parameters in a Large Population Sample

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dc.contributor.authorMazzotti, Diego Robles [UNIFESP]
dc.contributor.authorGuindalini, Camila [UNIFESP]
dc.contributor.authorPellegrino, Renata [UNIFESP]
dc.contributor.authorBarrueco, Karina Fonseca [UNIFESP]
dc.contributor.authorSantos-Silva, Rogerio [UNIFESP]
dc.contributor.authorBittencourt, Lia Rita Azeredo [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T12:12:00Z
dc.date.available2018-06-18T12:12:00Z
dc.date.issued2011-03-01
dc.description.abstractStudy Objectives: To evaluate the association between the adenosine deaminase polymorphism, sleep architecture, and caffeine consumption.Design: Genetic association study.Setting: NAPatients or Participants: 958 participants who underwent polysomnography and genotyping.Interventions: NAMeasurements and Results: Individuals carrying the A allele who consumed caffeine in the day prior to polysomnography demonstrated higher sleep efficiency and REM sleep percentage, after adjustment for potential confounders. No effect was observed in the absence of caffeine.Conclusions: Our data support the role of the ADA G22A polymorphism in sleep, and demonstrate for the first time that caffeine may act as a modulator of its functional effects.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psicobiol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psiquiatria, Lab Neurociencias Clin LiNC, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psicobiol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psiquiatria, Lab Neurociencias Clin LiNC, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Psicofarmacologia (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipIDFAPESP: 98/14303-3pt
dc.format.extent399-402
dc.identifierhttps://doi.org/10.1093/sleep/34.3.399
dc.identifier.citationSleep. Westchester: Amer Acad Sleep Medicine, v. 34, n. 3, p. 399-402, 2011.
dc.identifier.issn0161-8105
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/45611
dc.identifier.wosWOS:000287917600021
dc.language.isoeng
dc.publisherAmer Acad Sleep Medicine
dc.relation.ispartofSleep
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSleepen
dc.subjectAdenosine deaminaseen
dc.subjectCaffeine intakeen
dc.subjectPolymorphismen
dc.subjectSleep efficiencyen
dc.titleEffects of the Adenosine Deaminase Polymorphism and Caffeine Intake on Sleep Parameters in a Large Population Sampleen
dc.typeinfo:eu-repo/semantics/article
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