Fluctuation of annexin-A1 positive mast cells in chronic granulomatous inflammation

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dc.contributor.authorOliani, S. M. [UNIFESP]
dc.contributor.authorCiocca, G. A. Panin
dc.contributor.authorPimentel, T. A. [UNIFESP]
dc.contributor.authorDamazo, Amilcar Sabino [UNIFESP]
dc.contributor.authorGibbs, L.
dc.contributor.authorPerretti, M.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionWilliam Harvey Res Inst
dc.date.accessioned2016-01-24T13:51:43Z
dc.date.available2016-01-24T13:51:43Z
dc.date.issued2008-10-01
dc.description.abstractObjective: We have applied here a model of chronic granulomatous inflammation to study the profile of mast cell activation and their expression of annexin-A1 in the nodular lesion.Materials: Granulomatous inflammation was induced by injection of croton oil and Freund's complete adjuvant (CO/FCA) into the dorsal air-pouches of mice. Skin tissue samples were collected from control group (24 h time-point; i.e. before disease development) and 7, 14, 21, 28 and 42 days post-CO/FCA treatment.Results: Histopathological analyses revealed an on-going inflammation characterized by an increased number of activated mast cells at sites of the chronic inflammatory reaction in all experimental groups. Immunohistochemical analysis showed skin mast cells highly immunoreactive for annexin-A1, both at an initial (day 7) and a delayed (day 28) phase of the inflammatory reaction.Conclusions: the observed time-dependent modulation of mast cell activation, during the granulomatous injury, indicates that multiple pathways centred on annexin-A1 might become activated at different stages of this chronic inflammatory response, including the delayed and pro-resolving phase.en
dc.description.affiliationSão Paulo Univ UNESP, Inst Biociencias Letras & Ciencias Exatas IBILCE, Dept Biol, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUNIFESP EPM, BR-04023900 São Paulo, Brazil
dc.description.affiliationWilliam Harvey Res Inst, Ctr Biochem Pharmacol, Queen Mary Sch Med & Dent, London EC1M 6BQ, England
dc.description.affiliationUnifespUNIFESP EPM, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent450-456
dc.identifierhttp://dx.doi.org/10.1007/s00011-008-7222-7
dc.identifier.citationInflammation Research. Basel: Birkhauser Verlag Ag, v. 57, n. 10, p. 450-456, 2008.
dc.identifier.doi10.1007/s00011-008-7222-7
dc.identifier.issn1023-3830
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30932
dc.identifier.wosWOS:000261984800002
dc.language.isoeng
dc.publisherBirkhauser Verlag Ag
dc.relation.ispartofInflammation Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectLipocortin 1en
dc.subjectMast cellen
dc.subjectAir-pouch modelen
dc.subjectSkinen
dc.subjectNeutrophilen
dc.subjectGranulomaen
dc.titleFluctuation of annexin-A1 positive mast cells in chronic granulomatous inflammationen
dc.typeinfo:eu-repo/semantics/article
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