Plasma prekallikrein/kallikrein processing by lysosomal cysteine proteases

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dc.contributor.authorBarros, NMT
dc.contributor.authorPuzer, L.
dc.contributor.authorTersariol, ILS
dc.contributor.authorOliva, MLV
dc.contributor.authorSampaio, CAM
dc.contributor.authorCarmona, A. K.
dc.contributor.authorMotta, G. da
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUMC
dc.date.accessioned2016-01-24T12:37:29Z
dc.date.available2016-01-24T12:37:29Z
dc.date.issued2004-11-01
dc.description.abstractPlasma kallikrein plays a role in coagulation, fibrinolysis and inflammation. Cathepsins B and L participate in (patho)physiological processes such as peptide antigen processing, tissue remodeling events, protein turnover in cells, hormone processing and tumor invasion. the present work analyzes the processing of prekallikrein/kallikrein by lysosomal cathepsins. Prekallikrein is not hydrolyzed by catB, and catL generates an inactive fragment of prekallikrein. Both kallikrein chains are hydrolyzed by catL and the light chain is mainly hydrolyzed by catB; kallikrein activity is lower after incubation with catL compared to catB. Our data suggest that the plasma kallikrein/kinin system can be controlled by cathepsins.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Bioquim, EPM, BR-04044020 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biofes, BR-04044020 São Paulo, Brazil
dc.description.affiliationUMC, Ctr Interdisciplinar Invest Bioquim, BR-08701970 Mogi Das Cruzes, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Bioquim, EPM, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biofes, BR-04044020 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1087-1091
dc.identifierhttp://dx.doi.org/10.1515/BC.2004.141
dc.identifier.citationBiological Chemistry. Berlin: Walter de Gruyter & Co, v. 385, n. 11, p. 1087-1091, 2004.
dc.identifier.doi10.1515/BC.2004.141
dc.identifier.issn1431-6730
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28019
dc.identifier.wosWOS:000225438200014
dc.language.isoeng
dc.publisherWalter de Gruyter & Co
dc.relation.ispartofBiological Chemistry
dc.rightsAcesso restrito
dc.subjectcathepsinsen
dc.subjectkallikreinen
dc.subjectkinin systemen
dc.subjectproteolysisen
dc.titlePlasma prekallikrein/kallikrein processing by lysosomal cysteine proteasesen
dc.typeArtigo
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