Fish and omega-3 fatty acid intake in relation to circulating fibroblast growth factor 23 levels in renal transplant recipients

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dc.contributor.authorBaia, L. C. [UNIFESP]
dc.contributor.authorVan den Berg, E.
dc.contributor.authorVervloet, M. G.
dc.contributor.authorHeilberg, I. P. [UNIFESP]
dc.contributor.authorNavis, G.
dc.contributor.authorBakker, S. J. L.
dc.contributor.authorGeleijnse, J. M.
dc.contributor.authorKromhout, D.
dc.contributor.authorSoedamah-Muthu, S. S.
dc.contributor.authorDe Borst, M. H.
dc.contributor.authorNIGRAM Consortium
dc.contributor.institutionUniv Groningen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionVU Univ Med Ctr Amsterdam
dc.contributor.institutionWageningen Univ
dc.date.accessioned2016-01-24T14:38:16Z
dc.date.available2016-01-24T14:38:16Z
dc.date.issued2014-12-01
dc.description.abstractBackground and aims: A high circulating fibroblast growth factor 23 (FGF23) level is an independent risk factor for cardiovascular mortality in renal transplant recipients and the general population. N-3 fatty acids eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) may contribute to cardiovascular risk reduction. We investigated whether fish and EPA-DHA intake are related to FGF23 levels in renal transplant recipients.Methods and results: We performed a cross-sectional analysis in 619 stable renal transplant recipients (mean age 53 years, 57% male, estimated glomerular filtration rate [eGFR] 53 +/- 20 mL/min/1.73 m(2)). Dietary intake was assessed by a 177-item food frequency questionnaire. Serum intact FGF23 was measured by ELISA. We examined differences in FGF23 levels across categories of fish and EPA-DHA intake using analysis of variance models adjusted for age, sex, dietary and lifestyle factors and key determinants of FGF23. Patients consumed on average 15 g of fish and 139 mg EPA-DHA/day. Median FGF23 was 62 pg/mL (IQR 43-98 pg/mL). Higher dietary EPA-DHA and fish intake were associated with lower serum FGF23 levels. Subgroup analyses revealed that particularly in patients with reduced renal function (eGFR <60 mL/min/1.73 m(2)), adjusted FGF23 levels (114, 79, 75 pg/mL, P = 0.0001) were inversely associated with tertiles of EPA-DHA intake. Similarly, we observed an inverse association between fish consumption and serum FGF23 levels in adjusted analyses.Conclusion: A higher intake of fish and dietary n-3 fatty acids (EPA-DHA) is related to lower circulating FGF23 levels in renal transplant recipients. Further research is needed to assess the causality of this association and the clinical implications. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Groningen, Univ Med Ctr Groningen, Dept Nephrol, NL-9700 RB Groningen, Netherlands
dc.description.affiliationUniversidade Federal de São Paulo, Dept Nephrol, São Paulo, Brazil
dc.description.affiliationVU Univ Med Ctr Amsterdam, Dept Nephrol, Amsterdam, Netherlands
dc.description.affiliationWageningen Univ, Div Human Nutr, NL-6700 AP Wageningen, Netherlands
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Nephrol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipDutch Kidney Foundation (NIGRAM consortium)
dc.description.sponsorshipDutch Kidney foundation (MHdB)
dc.description.sponsorshipUniversity Medical Center Groningen (MHdB)
dc.description.sponsorshipNetherlands Organization for Scientific Research (Veni grant)
dc.description.sponsorshipTop Institute Food and Nutrition (EvdB)
dc.description.sponsorshipRoyal Netherlands Academy of Arts and Sciences
dc.description.sponsorshipIDDutch Kidney Foundation (NIGRAM consortium): CP10.11
dc.description.sponsorshipIDTop Institute Food and Nutrition (EvdB): TIFN A1003
dc.format.extent1310-1316
dc.identifierhttp://dx.doi.org/10.1016/j.numecd.2014.06.006
dc.identifier.citationNutrition Metabolism and Cardiovascular Diseases. Oxford: Elsevier B.V., v. 24, n. 12, p. 1310-1316, 2014.
dc.identifier.doi10.1016/j.numecd.2014.06.006
dc.identifier.issn0939-4753
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38516
dc.identifier.wosWOS:000348043200007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNutrition Metabolism and Cardiovascular Diseases
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectOmega-3 fatty acidsen
dc.subjectFibroblast growth factoren
dc.subjectCardiovascularen
dc.subjectKidney transplantationen
dc.titleFish and omega-3 fatty acid intake in relation to circulating fibroblast growth factor 23 levels in renal transplant recipientsen
dc.typeinfo:eu-repo/semantics/article
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