PREGNANT-WOMEN WITH ENDEMIC PEMPHIGUS FOLIACEUS (FOGO SELVAGEM) GIVE BIRTH TO DISEASE-FREE BABIES

Página do item simplificado
dc.contributor.authorAlvarez, Rosicler Rocha Aiza [UNIFESP]
dc.contributor.authorFriedman, Horácio
dc.contributor.authorCampbell, Iphis T.
dc.contributor.authorSouza-Aguiar, Ligia
dc.contributor.authorCastro, Raymundo Martins de [UNIFESP]
dc.contributor.authorDiaz, Luis A.
dc.contributor.institutionMED COLL WISCONSIN
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.date.accessioned2016-01-24T11:40:07Z
dc.date.available2016-01-24T11:40:07Z
dc.date.issued1992-07-01
dc.description.abstractEndemic pemphigus foliaceus (PF), also known as Fogo Selvagem (FS), is an organ-specific autoimmune disease mediated by autoantibodies. These autoantibodies are disease specific, predominantly restricted to the IgG4 subclass, and pathogenic, as demonstrated by passive transfer studies. in contrast to pemphigus vulgaris, neonatal skin disease does not appear to occur in babies born to mothers with non-endemic PF or FS. in the present study we have examined 19 mother/neonate pairs where the mother had documented FS. Mothers and neonates were examined soon after delivery and tested by immunofluorescent (IF) techniques for FS autoantibodies either in circulation (mothers' sera or babies' cord blood) or bound to the neonatal epidermis. All neonates included in this study were born with normal skin. Twelve biopsies from 17 neonates showed negative direct IF using both FITC-antihuman IgG or monoclonal anti-IgG subclass antibodies. in five biopsies the epidermal ICS of the babies showed weak staining. in 10 of the 19 cord sera tested, FS IgG autoantibodies were undetectable; in nine, these autoantibodies were present in low titers (< 1 : 40). the sera of the mothers showed higher titers of FS autoantibodies, and IgG4 was the predominant IgG subclass autoantibodies. It appears that human placenta may modulate the expression of disease in the newborn by operating as a biologic immunoadsorbent of pathogenic autoantibodies.en
dc.description.affiliationMED COLL WISCONSIN,DEPT DERMATOL,8701 WATERTOWN PLANK RD,MILWAUKEE,WI 53226
dc.description.affiliationESCOLA PAULISTA MED SCH,DEPT DERMATOL,BR-04023 São Paulo,BRAZIL
dc.description.affiliationFUNDACAO UNIV BRASILIA,DEPT DERMATOL,São Paulo,BRAZIL
dc.description.affiliationFUNDACAO UNIV BRASILIA,DEPT PATHOL,São Paulo,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED SCH,DEPT DERMATOL,BR-04023 São Paulo,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent78-82
dc.identifierhttp://dx.doi.org/10.1111/1523-1747.ep12611868
dc.identifier.citationJournal of Investigative Dermatology. Malden: Blackwell Science Inc, v. 99, n. 1, p. 78-82, 1992.
dc.identifier.doi10.1111/1523-1747.ep12611868
dc.identifier.issn0022-202X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25259
dc.identifier.wosWOS:A1992JB43700013
dc.language.isoeng
dc.publisherBlackwell Science Inc
dc.relation.ispartofJournal of Investigative Dermatology
dc.rightsAcesso aberto
dc.titlePREGNANT-WOMEN WITH ENDEMIC PEMPHIGUS FOLIACEUS (FOGO SELVAGEM) GIVE BIRTH TO DISEASE-FREE BABIESen
dc.typeArtigo
Arquivos
Coleções
Em verificação - Geral