What do Cochrane systematic reviews say about interventions for autism spectrum disorders?

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dc.citation.issue2
dc.citation.volume135
dc.contributor.authorLyra, Larissa [UNIFESP]
dc.contributor.authorRizzo, Luiz Eduardo [UNIFESP]
dc.contributor.authorSunahara, Camila Sa [UNIFESP]
dc.contributor.authorPachito, Daniela Vianna [UNIFESP]
dc.contributor.authorCruz Latorraca, Carolina de Oliveira [UNIFESP]
dc.contributor.authorCabrera Martimbianco, Ana Luiza
dc.contributor.authorRiera, Rachel [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-07-17T14:02:43Z
dc.date.available2020-07-17T14:02:43Z
dc.date.issued2017
dc.description.abstractCONTEXT AND OBJECTIVE: Autism spectrum disorders (ASDs) include autistic disorder, Asperger's disorder and pervasive developmental disorder. The manifestations of ASDs can have an important impact on learning and social functioning that may persist during adulthood. The aim here was to summarize the evidence from Cochrane systematic reviews on interventions for ASDs. DESIGN AND SETTING: Review of systematic reviews, conducted within the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina, Universidade Federal de Sao Paulo. METHODS: We included and summarized the results from Cochrane systematic reviews on interventions for ASDs. RESULTS: Seventeen reviews were included. These found weak evidence of benefits from acupuncture, gluten and casein-free diets, early intensive behavioral interventions, music therapy, parent-mediated early interventions, social skill groups, Theory of Mind cognitive model, aripiprazole, risperidone, tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRI)en
dc.description.abstractthis last only for adults. No benefits were found for sound therapies, chelating agents, hyperbaric oxygen therapy, omega-3, secretin, vitamin B6/magnesium and SSRI for children. CONCLUSION: Acupuncture, gluten and casein-free diets, early intensive behavioral interventions, music therapy, parent-mediated early interventions, social skill groups and the Theory of Mind cognitive model seem to have benefits for patients with autism spectrum disorders (very low to low-quality evidence). Aripiprazole, risperidone, tricyclic antidepressants and SSRI (this last only for adults) also showed some benefits, although associated with higher risk of adverse events. Experimental studies to confirm a link between probable therapies and the disease, and then high-quality long-term clinical trials, are needed.en
dc.description.affiliationUniv Fed Sao Paulo Unifesp, EPM, Discipline Evidence Based Med, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo Unifesp, EPM, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Evidence Based Hlth Program, Sao Paulo, SP, Brazil
dc.description.affiliationCochrane Brazil, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, EPM, Discipline Evidence Based Med, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, EPM, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, Evidence Based Hlth Program, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent192-201
dc.identifierhttp://dx.doi.org/10.1590/1516-3180.2017.0058200317
dc.identifier.citationSao Paulo Medical Journal. Sao Paulo, v. 135, n. 2, p. 192-201, 2017.
dc.identifier.doi10.1590/1516-3180.2017.0058200317
dc.identifier.fileWOS000402009700017.pdf
dc.identifier.issn1516-3180
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54964
dc.identifier.wosWOS:000402009700017
dc.language.isoeng
dc.publisherAssociacao Paulista Medicina
dc.relation.ispartofSao Paulo Medical Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAutism spectrum disorderen
dc.subjectTherapeuticsen
dc.subjectReview [Publication type]en
dc.subjectEvidence-based practiceen
dc.subjectEvidence-based medicineen
dc.titleWhat do Cochrane systematic reviews say about interventions for autism spectrum disorders?en
dc.typeinfo:eu-repo/semantics/article
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