Emended description of Mycobacterium abscessus, Mycobacterium abscessus subsp abscessus and Mycobacterium abscessus subsp bolletii and designation of Mycobacterium abscessus subsp massiliense comb. nov.

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dc.citation.volume66
dc.contributor.authorTortoli, Enrico
dc.contributor.authorKohl, Thomas A.
dc.contributor.authorBrown-Elliott, Barbara A.
dc.contributor.authorTrovato, Alberto
dc.contributor.authorLeao, Sylvia Cardoso [UNIFESP]
dc.contributor.authorJesus Garcia, Maria
dc.contributor.authorVasireddy, Sruthi
dc.contributor.authorTurenne, Christine Y.
dc.contributor.authorGriffith, David E.
dc.contributor.authorPhiIley, Julie V.
dc.contributor.authorBaldan, Rossella
dc.contributor.authorCampana, Silvia
dc.contributor.authorCariani, Lisa
dc.contributor.authorColombo, Carla
dc.contributor.authorTaccetti, Giovanni
dc.contributor.authorTeri, Antonio
dc.contributor.authorNiemann, Stefan
dc.contributor.authorWallace, Richard J., Jr.
dc.contributor.authorCirillo, Daniela M.
dc.coverageLondon
dc.date.accessioned2020-07-31T12:47:22Z
dc.date.available2020-07-31T12:47:22Z
dc.date.issued2016
dc.description.abstractThe taxonomic position of members of the Mycobacterium abscessus complex has been the subject of intensive investigation and, in some aspects confusion, in recent years as a result of varying approaches to genetic data interpretation. Currently, the former species Mycobacterium massiliense and Mycobacterium bolletii are grouped together as Mycobacterium abscessus subsp. bolletii. They differ greatly, however, as the former M. bolletii has a functional erm(41) gene that confers inducible resistance to macrolides, the primary therapeutic antimicrobials for M. abscessus, while in the former M. massiliense the erm(41) gene is non-functional. Furthermore, previous whole genome studies of the M. abscessus group support the separation of M. bolletii and M. massiliense. To shed further light on the population structure of Mycobacterium abscessus, 43 strains and three genomes retrieved from GenBank were subjected to pairwise comparisons using three computational approaches: verage ucleotide dentity, enome to enome istance and single nucleotide polymorphism analysis. The three methods produced overlapping results, each demonstrating three clusters of strains corresponding to the same number of taxonomic entities. The distances were insufficient to warrant distinction at the species level, but met the criteria for differentiation at the subspecies level. Based on prior erm(41)-related phenotypic data and current genomic data, we conclude that the species M. abscessus encompasses, in adjunct to the presently recognized subspecies M. abscessus subsp. abscessus and M. abscessus subsp. bolletii, a third subspecies for which we suggest the name M. abscessus subsp. massiliense comb. nov. (type strain CCUG 48898(T) =CIP 108297(T) =DSM 45103(T) = KCTC 19086(T)).en
dc.description.affiliationIst Sci San Raffaele, Emerging Bacterial Pathogens Unit, Milan, Italy
dc.description.affiliationLeibniz Zentrum Med & Biowissensch, Mol & Expt Mycobacteriol, Borstel, Germany
dc.description.affiliationUniv Texas Hlth Ctr Tyler, Dept Microbiol, Mycobact Nocardia Res Lab, Tyler, TX USA
dc.description.affiliationUniv Fed Sao Paulo, Escol Paulista Med, Dept Microbiol Imunol & Parasiotol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Madrid, Dept Prevent Med Publ Hlth & Microbiol, Madrid, Spain
dc.description.affiliationDiagnost Serv Manitoba, Winnipeg, MB, Canada
dc.description.affiliationUniv Texas Hlth Sci Ctr Tyler, Dept Pulm Med, Tyler, TX USA
dc.description.affiliationMeyer Univ Hosp, Reg Reference Ctr Cyst Fibrosis, Florence, Italy
dc.description.affiliationIRCCS Ca Granda, Cyst Fibrosis Microbiol Lab, Milan, Italy
dc.description.affiliationIRCCS Ca Granda, Cyst Fibrosis Ctr, Milan, Italy
dc.description.affiliationUnifespDepartamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipresearch grants FFC from Fondazione Ricerca Fibrosi Cistica
dc.description.sponsorshipEuropean Union PathoNgen-Trace project
dc.description.sponsorshipGerman Center for Infection Research (DZIF)
dc.description.sponsorshipIDresearch grants FFC from Fondazione Ricerca Fibrosi Cistica: 27/2014
dc.description.sponsorshipIDEuropean Union PathoNgen-Trace project: FP7-278864-2
dc.format.extent4471-4479
dc.identifierhttp://dx.doi.org/10.1099/ijsem.0.001376
dc.identifier.citationInternational Journal Of Systematic And Evolutionary Microbiology. London, v. 66, p. 4471-4479, 2016.
dc.identifier.doi10.1099/ijsem.0.001376
dc.identifier.issn1466-5026
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56773
dc.identifier.wosWOS:000390686600025
dc.language.isoeng
dc.publisherMicrobiology Soc
dc.relation.ispartofInternational Journal Of Systematic And Evolutionary Microbiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEmended description of Mycobacterium abscessus, Mycobacterium abscessus subsp abscessus and Mycobacterium abscessus subsp bolletii and designation of Mycobacterium abscessus subsp massiliense comb. nov.en
dc.typeinfo:eu-repo/semantics/article
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