Chlamydia trachomatis and Neisseria gonorrhoeae in HIV-infected Pregnant Women and Adverse Infant Outcomes

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dc.citation.issue8
dc.citation.volume35
dc.contributor.authorAdachi, Kristina
dc.contributor.authorKlausner, Jeffrey D.
dc.contributor.authorXu, Jiahong
dc.contributor.authorAnk, Bonnie
dc.contributor.authorBristow, Claire C.
dc.contributor.authorMorgado, Mariza G.
dc.contributor.authorWatts, D. Heather
dc.contributor.authorWeir, Fred
dc.contributor.authorPersing, David
dc.contributor.authorMofenson, Lynne M.
dc.contributor.authorVeloso, Valdilea G.
dc.contributor.authorPilotto, Jose Henrique
dc.contributor.authorJoao, Esau
dc.contributor.authorGray, Glenda
dc.contributor.authorTheron, Gerhard
dc.contributor.authorSantos, Breno
dc.contributor.authorFonseca, Rosana
dc.contributor.authorKreitchmann, Regis
dc.contributor.authorPinto, Jorge
dc.contributor.authorMussi-Pinhata, Marisa M.
dc.contributor.authorCeriotto, Mariana
dc.contributor.authorMachado, Daisy Maria [UNIFESP]
dc.contributor.authorBryson, Yvonne J.
dc.contributor.authorGrinsztejn, Beatriz
dc.contributor.authorBastos, Francisco I.
dc.contributor.authorSiberry, George
dc.contributor.authorNielsen-Saines, Karin
dc.coveragePhiladelphia
dc.date.accessioned2020-08-14T13:44:00Z
dc.date.available2020-08-14T13:44:00Z
dc.date.issued2016
dc.description.abstractBackground: Sexually transmitted infections (STIs) in pregnancy such as Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) may lead to adverse infant outcomes. Methods: Individual urine specimens from HIV-infected pregnant women diagnosed with HIV during labor were collected at the time of infant birth and tested by polymerase chain reaction for CT and NG. Infant HIV infection was determined at 3 months with morbidity/mortality assessed through 6 months. Results: Of 1373 maternal urine samples, 277 (20.2%) were positive for CT and/or NGen
dc.description.abstract249 (18.1%) for CT, 63 (4.6%) for NG and 35 (2.5%) for both CT and NG. HIV infection was diagnosed in 117 (8.5%) infants. Highest rates of adverse outcomes (sepsis, pneumonia, congenital syphilis, septic arthritis, conjunctivitis, low birth weight, preterm delivery and death) were noted in infants of women with CT and NG (23/35, 65.7%) compared with NG (16/28, 57.1%), CT (84/214, 39.3%) and no STI (405/1096, 37%, P = 0.001). Death (11.4% vs. 3%, P = 0.02), low birth weight (42.9% vs. 16.9%, P = 0.001) and preterm delivery (28.6% vs. 10.2%, P = 0.008) were higher among infants of CT and NG-coinfected women. Infants who had any adverse outcome and were born to women with CT and/or NG were 3.5 times more likely to be HIV infected after controlling for maternal syphilis (odds ratio: 3.5, 95% confidence interval: 1.4-8.3). By adjusted multivariate logistic regression, infants born to mothers with any CT and/or NG were 1.35 times more likely to have an adverse outcome (odds ratio, 1.35en
dc.description.abstract95% confidence interval, 1.03-1.76). Conclusions: STIs in HIV-infected pregnant women are associated with adverse outcomes in HIV-exposed infected and uninfected infants.en
dc.description.affiliationDavid Geffen UCLA Sch Med, Los Angeles, CA USA
dc.description.affiliationUCLA Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA
dc.description.affiliationWESTAT Corp, Rockville, MD 20850 USA
dc.description.affiliationFundacao Oswaldo Cruz FIOCRUZ, Rio De Janeiro, Brazil
dc.description.affiliationUS Dept State, Off Global AIDS Coordinator, Washington, DC 20520 USA
dc.description.affiliationCepheid, Sunnyvale, CA USA
dc.description.affiliationEunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA
dc.description.affiliationHosp Geral Nova Iguacu, DST AIDS, Rio De Janeiro, Brazil
dc.description.affiliationHosp Fed Servidores Estado, Rio De Janeiro, Brazil
dc.description.affiliationUniv Witwatersrand, SAMRC, Cape Town, South Africa
dc.description.affiliationUniv Witwatersrand, Perinatal HIV Res Unit, Cape Town, South Africa
dc.description.affiliationUniv Stellenbosch, Tygerberg Hosp, Dept Obstet & Gynecol, Cape Town, South Africa
dc.description.affiliationHosp Conceicao, Serv Infectol, Porto Alegre, RS, Brazil
dc.description.affiliationHosp Femina, Porto Alegre, RS, Brazil
dc.description.affiliationIrmandade Santa Casa de Misericordia Porto Alegre, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Dept Pediat, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Sao Paulo, Ribeirao Preto Med Sch, Dept Pediat, Sao Paulo, Brazil
dc.description.affiliationFdn Maternal & Infant Hlth FUNDASAMIN, Buenos Aires, DF, Argentina
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNICHD
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases (NIAID)/NIH
dc.description.sponsorshipNational Institutes of Health (NIH)
dc.description.sponsorshipEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
dc.description.sponsorshipNational Institute of Mental Health
dc.description.sponsorshipBoehringer Ingelheim Pharmaceuticals Inc. (BIPI)
dc.description.sponsorshipGlaxoSmithKline on behalf of ViiV Healthcare
dc.description.sponsorshipCepheid, Sunnyvale, CA
dc.description.sponsorshipUCLA Center for AIDS Research (CFAR) NIH/NIAID
dc.description.sponsorshipIDNICHD: HHSN267200800001C
dc.description.sponsorshipIDNICHD: N01-HD-8-0001
dc.description.sponsorshipIDNICHD: U01 AI047986
dc.description.sponsorshipIDNIH: NIAIDU01 AI068632
dc.description.sponsorshipIDNIH: UM1AI068632
dc.description.sponsorshipIDNIH: UM1AI068616
dc.description.sponsorshipIDNIH: UM1AI106716
dc.description.sponsorshipIDNational Institute of Mental Health: AI068632
dc.description.sponsorshipIDUCLA Center for AIDS Research (CFAR) NIH/NIAID: AI028697
dc.format.extent894-900
dc.identifierhttp://dx.doi.org/10.1097/INF.0000000000001199
dc.identifier.citationPediatric Infectious Disease Journal. Philadelphia, v. 35, n. 8, p. 894-900, 2016.
dc.identifier.doi10.1097/INF.0000000000001199
dc.identifier.fileWOS000380755000018.pdf
dc.identifier.issn0891-3668
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57479
dc.identifier.wosWOS:000380755000018
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofPediatric Infectious Disease Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHIVen
dc.subjectpregnancyen
dc.subjectchlamydiaen
dc.subjectgonorrheaen
dc.subjectsexually transmitted infectionsen
dc.subjectadverse infant outcomesen
dc.titleChlamydia trachomatis and Neisseria gonorrhoeae in HIV-infected Pregnant Women and Adverse Infant Outcomesen
dc.typeinfo:eu-repo/semantics/article
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