Birth Weight and Its Relationship with the Cardiac Autonomic Balance in Healthy Children

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dc.citation.issue1
dc.citation.volume12
dc.contributor.authorSouza, Livia Victorino [UNIFESP]
dc.contributor.authorOliveira, Vanessa [UNIFESP]
dc.contributor.authorMeneck, Franciele de [UNIFESP]
dc.contributor.authorClemente, Ana Paula Grotti
dc.contributor.authorStrufaldi, Maria Wany Louzada [UNIFESP]
dc.contributor.authorFranco, Maria do Carmo Pinho [UNIFESP]
dc.coverageSan Francisco
dc.date.accessioned2020-07-17T14:03:14Z
dc.date.available2020-07-17T14:03:14Z
dc.date.issued2017
dc.description.abstractSeveral studies indicate that the fetal environment plays a significant role in the development of cardiometabolic disease later in life. However, a few studies present conflicting data about the correlation between birth weight and the impairment of cardiac autonomic modulation. The purpose of the present study was to provide further knowledge to elucidate this contradictory relationship. One hundred children aged 5 and 14 years had anthropometric parameters, body composition and blood pressure levels determined. Heart rate variability (HRV) was evaluated by heart rate monitoring, including measurements of both the time and frequency domains. The results showed inverse correlation between the HRV parameters with BMI (RMSSD: P = 0.047; PNN50: P = 0.021; HF: P = 0.041), systolic (RMSSD: P = 0.023; PNN50: P = 0.032) and diastolic (PNN50: P = 0.030) blood pressure levels. On the other hand, there were consistent positive correlations between the HRV parameters and birth weight (RMSSD: P = 0.001; PNN50: P = 0.001; HF: P = 0.002). To determine the effect of birth weight on HRV parameters, we perform multivariate linear regression analysis adjusted for potentially confounding factors (prematurity, gender, age, BMI, physical activity index and SBP levels). These findings were preserved even after adjusting for these confounders. Our results suggested that impaired cardiac autonomic modulation characterized by a reduction in the parasympathetic activity occurs in children with low birth weight. One possible interpretation for these data is that a vagal withdrawal, rather than a sympathetic overactivity, could precede the development of hypertension and other cardiometabolic diseases in children with low birth weight. However, long-term studies should be performed to investigate this possibility.en
dc.description.affiliationUniv Fed Sao Paulo, Div Nephrol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Alagoas, Dept Nutr, Alagoas, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Nephrol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2013/03139-0
dc.format.extent-
dc.identifierhttps://dx.doi.org/10.1371/journal.pone.0167328
dc.identifier.citationPlos One. San Francisco, v. 12, n. 1, p. -, 2017.
dc.identifier.doi10.1371/journal.pone.0167328
dc.identifier.fileWOS000392372300004.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55238
dc.identifier.wosWOS:000392372300004
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleBirth Weight and Its Relationship with the Cardiac Autonomic Balance in Healthy Childrenen
dc.typeinfo:eu-repo/semantics/article
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