The high glycemic index diet was an independent predictor to explain changes in agouti-related protein in obese adolescents

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dc.contributor.authorDal Molin Netto, Bárbara [UNIFESP]
dc.contributor.authorMasquio, Deborah Cristina Landi [UNIFESP]
dc.contributor.authorCampos, Raquel Munhoz da Silveira [UNIFESP]
dc.contributor.authorSanches, Priscila de Lima [UNIFESP]
dc.contributor.authorCorgosinho, Flavia Campos [UNIFESP]
dc.contributor.authorTock, Lian
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:35:11Z
dc.date.available2016-01-24T14:35:11Z
dc.date.issued2014-02-01
dc.description.abstractThe high glycemic index diet was an independent predictor to explain changes in agouti-related protein in obese adolescents.Background & Aims: the role of diet glycemic index (GI) in the control of orexigenic and anorexigenic factors of the energy balance is still not clear. the present study aimed to assess whether the habitual diet, according to different GI foods, exerts influence on regulation of energy balance markers and the effects of interdisciplinary intervention in obese adolescents.Methods: A total of 55 obese adolescents, aged from 14 to 19 years, were submited to one year of interdisciplinary therapy and were divided in two groups, according to the predominant dietary pattern of food intake: high-GI group (H-GI; n = 29) and moderate/low-GI group (M/L-GI; n = 26).Results: the concentration of orexigenic factor AgRP (p < 0.01), visceral fat (p = 0.04) and visceral/subcutaneous ratio (p = 0.03) were higher in the group of H-GI when compared with M/L-GI group. Moreover, the habitual consumption of H-GI foods was an independent predictor to explain changes in AgRP concentrations. After one year of interdisciplinary therapy, the adolescents presented significant reductions in body weight, total body fat (%), visceral and subcutaneous fat and HOMA-IR, as well as a significant increase of fat free mass (%).Conclusions: Our results may suggest that habitual H-GI diet could upregulate orexigenic pathways, contributing to vicious cycle between undesirable diets, deregulates energy balance and predispose to obesity. One the other hand, one year of interdisciplinary therapy can significant improves metabolic profile and central obesity in adolescents.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, UNIFESP EPM, São Paulo, Brazil
dc.description.affiliationUNIFESP EPM, Post Grad Program Nutr, São Paulo, Brazil
dc.description.affiliationUNIFESP EPM, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUNIFESP EPM, Dept Biosci, São Paulo, Brazil
dc.description.affiliationUNIFESP EPM, Post Grad Program Interdisciplinary Hlth Sci, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, UNIFESP EPM, São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP EPM, Post Grad Program Nutr, São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP EPM, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP EPM, Dept Biosci, São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP EPM, Post Grad Program Interdisciplinary Hlth Sci, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAFIP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipCENESP
dc.description.sponsorshipFADA
dc.description.sponsorshipUNIFESP-EPM
dc.description.sponsorshipIDAFIP: 2011/50356-0
dc.description.sponsorshipIDAFIP: 2011/50414-0
dc.description.sponsorshipIDAFIP: 2013/04136-4
dc.description.sponsorshipIDFAPESP: 9814303-3
dc.description.sponsorshipIDCAPES: 2566/2011
dc.format.extent305-314
dc.identifierhttps://dx.doi.org/10.3305/nh.2014.29.2.7087
dc.identifier.citationNutricion Hospitalaria. Madrid: Aula Medica Ediciones, v. 29, n. 2, p. 305-314, 2014.
dc.identifier.doi10.3305/nh.2014.29.2.7087
dc.identifier.fileWOS000331918800009.pdf
dc.identifier.issn0212-1611
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/37351
dc.identifier.wosWOS:000331918800009
dc.language.isoeng
dc.publisherAula Medica Ediciones
dc.relation.ispartofNutricion Hospitalaria
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectObesityen
dc.subjectEnergy balanceen
dc.subjectNeuropeptidesen
dc.subjectFood consumptionen
dc.subjectGlycemic indexen
dc.titleThe high glycemic index diet was an independent predictor to explain changes in agouti-related protein in obese adolescentsen
dc.title.alternativeLa dieta de alto índice glucémico es un predictor independiente para explicar los cambios en la proteína relacionada al agouti en adolescentes obesoses
dc.typeinfo:eu-repo/semantics/article
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