Adrenalectomy abolishes the food-induced hypothalamic serotonin release in both normal and monosodium glutamate-obese rats

Página do item simplificado
dc.contributor.authorGuimaraes, Regina Barros [UNIFESP]
dc.contributor.authorTelles, Monica Marques [UNIFESP]
dc.contributor.authorCoelho, Vivian Beatriz Orlandin [UNIFESP]
dc.contributor.authorMori, Rosana Cristina Tieko [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorRibeiro, Eliane Beraldi [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:33:29Z
dc.date.available2016-01-24T12:33:29Z
dc.date.issued2002-08-15
dc.description.abstractCorticosteroids influence energy homeostasis through centrally-mediated stimulation of energy intake and inhibition of expenditure, while central serotonin (5-HT) has opposite effects. Both serotonergic dysfunction and high glucocorticoid levels may be relevant in obesity. the neurotoxin monosodium glutamate (MSG) induces a non-hyperphagic and hypometabolic obesity with hypercorticosteronemia. We investigated the influence of corticosterone levels on the serotonergic system of MSG-obese and control rats. Applying microdialysis, we found a similar feeding-induced stimulation of serotonin release in the lateral hypothalamus (LH) in sham-adrenalectomized control and MSG rats. the concomitant serum corticosterone variations were markedly distinct between them, in that an increase occurred in the control group, while the initially high levels of the MSG rats decreased with feeding. It is suggested that this lowering of corticosterone prevented a higher serotonergic activation, which would lead to a higher meal-induced thermogenesis and a better adequation of the,caloric intake to a low metabolism. Adrenalectomy completely abolished the feeding-evoked serotonergic stimulation in both groups. This observation demonstrates that glucocorticoids are necessary for food intake to acutely stimulate 5-HT release and indicates that serotonergic activity in the LH is not likely to participate in the adrenalectomy-induced attenuation of the MSG-obesity. (C) 2002 Elsevier Science Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent363-369
dc.identifierhttps://dx.doi.org/10.1016/S0361-9230(02)00799-2
dc.identifier.citationBrain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 58, n. 4, p. 363-369, 2002.
dc.identifier.doi10.1016/S0361-9230(02)00799-2
dc.identifier.issn0361-9230
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/26948
dc.identifier.wosWOS:000178267000004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research Bulletin
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectFood intakeen
dc.subjectLateral hypothalamusen
dc.subjectCorticosteroneen
dc.subjectEnergy balanceen
dc.subjectBrain microdialysisen
dc.titleAdrenalectomy abolishes the food-induced hypothalamic serotonin release in both normal and monosodium glutamate-obese ratsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos