Correlation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variables

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dc.contributor.authorMacêdo, G.s.
dc.contributor.authorFerreira, Carolina.l.p.
dc.contributor.authorMenegaz, Andressa
dc.contributor.authorArantes, Vanessa Cristina
dc.contributor.authorVeloso, Roberto Vilela
dc.contributor.authorCarneiro, Everardo Magalhães
dc.contributor.authorBoschero, Antonio Carlos
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorLatorraca, Marcia Queiroz
dc.contributor.authorGomes-da-Silva, Maria Helena Gaiva
dc.contributor.institutionUniversidade Federal de Mato Grosso Faculdade de Ciências Médicas
dc.contributor.institutionUniversidade Federal de Mato Grosso Faculdade de Nutrição Departamento de Alimentos e Nutrição
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:38:35Z
dc.date.available2015-06-14T13:38:35Z
dc.date.issued2008-06-01
dc.description.abstractDuring pregnancy and protein restriction, changes in serum insulin and leptin levels, food intake and several metabolic parameters normally result in enhanced adiposity. We evaluated serum leptin and insulin levels and their correlations with some predictive obesity variables in Wistar rats (90 days), up to the 14th day of pregnancy: control non-pregnant (N = 5) and pregnant (N = 7) groups (control diet: 17% protein), and low-protein non-pregnant (N = 5) and pregnant (N = 6) groups (low-protein diet: 6%). Independent of the protein content of the diet, pregnancy increased total (F1,19 = 22.28, P < 0.001) and relative (F1,19 = 5.57, P < 0.03) food intake, the variation of weight (F1,19 = 49.79, P < 0.000) and final body weight (F1,19 = 19.52, P < 0.001), but glycemia (F1,19 = 9.02, P = 0.01) and the relative weight of gonadal adipose tissue (F1,19 = 17.11, P < 0.001) were decreased. Pregnancy (F1,19 = 18.13, P < 0.001) and low-protein diet (F1,19 = 20.35, P < 0.001) increased the absolute weight of brown adipose tissue. However, the relative weight of this tissue was increased only by protein restriction (F1,19 = 15.20, P < 0.001) and the relative lipid in carcass was decreased in low-protein groups (F1,19 = 4.34, P = 0.05). Serum insulin and leptin levels were similar among groups and did not correlate with food intake. However, there was a positive relationship between serum insulin levels and carcass fat depots in low-protein groups (r = 0.37, P < 0.05), while in pregnancy serum leptin correlated with weight of gonadal (r = 0.39, P < 0.02) and retroperitoneal (r = 0.41, P < 0.01) adipose tissues. Unexpectedly, protein restriction during 14 days of pregnancy did not alter the serum profile of adiposity signals and their effects on food intake and adiposity, probably due to the short term of exposure to low-protein diet.en
dc.description.affiliationUniversidade Federal de Mato Grosso Faculdade de Ciências Médicas
dc.description.affiliationUniversidade Federal de Mato Grosso Faculdade de Nutrição Departamento de Alimentos e Nutrição
dc.description.affiliationUniversidade Estadual de Campinas Instituto de Biologia Departamento de Fisiologia e Biofísica
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Fisiologia da Nutrição
dc.description.affiliationUnifespUNIFESP, Depto. de Fisiologia da Nutrição
dc.description.sourceSciELO
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipBrazilian Foundations FAPEMAT
dc.description.sponsorshipIDBrazilian Foundations FAPEMAT: 175/04
dc.description.sponsorshipIDCNPq: 479138/2003-6
dc.format.extent519-525
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2008000600014
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 6, p. 519-525, 2008.
dc.identifier.doi10.1590/S0100-879X2008000600014
dc.identifier.fileS0100-879X2008000600014.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2008000600014
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/4411
dc.identifier.wosWOS:000258766600014
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso aberto
dc.subjectLow-protein dieten
dc.subjectPregnancyen
dc.subjectSerum leptinen
dc.subjectSerum insulinen
dc.subjectBody adiposityen
dc.titleCorrelation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variablesen
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