Expression of HOXC9 and E2F2 are up-regulated in CD133+cells isolated from human astrocytomas and associate with transformation of human astrocytes

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dc.contributor.authorOkamoto, Oswaldo K.
dc.contributor.authorOba-Shinjo, Sueli M.
dc.contributor.authorLopes, Luciana
dc.contributor.authorMarie, Suely K. Nagahashi
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Israelita Ensino & Pesquisa Albert Einstein
dc.date.accessioned2016-01-24T13:48:50Z
dc.date.available2016-01-24T13:48:50Z
dc.date.issued2007-07-01
dc.description.abstractComparative analysis of cancer stem cells with their neoplastic and non-neoplastic counterparts should help better understand the underlying molecular events leading to transformation and tumor dissemination. Here, we report a molecular signature comprised by genes with exclusive aberrant expression in CD133+ cells, a reported subpopulation of tumorigenic stem-like cells, isolated from human glioblastomas. Microarrays covering 55,000 transcripts were used to compare gene expression profiles in purified subpopulations of CD133+ and CD133- GBM cells. Sixteen genes, many of which not previously associated with astrocytomas, were found aberrantly expressed in CD133+ cells, but not in CD133-, when compared with corresponding non-neoplastic controls. Up-regulation of two of such genes, E2F2 and HOXC9, was detected in a set of 54 astrocytomas of different grades and significantly associated with malignancy. Due to their distinctive expression in CD133+ cells, the use of E2F2 and HOXC9 as therapeutic targets for tumor eradication is suggested. (c) 2007 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Disciplina Neurol Expt, Dept Neurol & Neurocirurgia, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Sch Med, Dept Neurol, BR-05403900 São Paulo, Brazil
dc.description.affiliationInst Israelita Ensino & Pesquisa Albert Einstein, BR-05651901 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Disciplina Neurol Expt, Dept Neurol & Neurocirurgia, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Sch Med, Dept Neurol, BR-05403900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent437-442
dc.identifierhttp://dx.doi.org/10.1016/j.bbaexp.2007.05.002
dc.identifier.citationBiochimica Et Biophysica Acta-gene Structure and Expression. Amsterdam: Elsevier B.V., v. 1769, n. 7-8, p. 437-442, 2007.
dc.identifier.doi10.1016/j.bbaexp.2007.05.002
dc.identifier.issn0167-4781
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29851
dc.identifier.wosWOS:000248898400002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBiochimica Et Biophysica Acta-gene Structure and Expression
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectcancer stem cellen
dc.subjectCD133en
dc.subjectglioblastomaen
dc.subjectastrocytomaen
dc.subjectmalignancyen
dc.subjectmicroarrayen
dc.titleExpression of HOXC9 and E2F2 are up-regulated in CD133+cells isolated from human astrocytomas and associate with transformation of human astrocytesen
dc.typeinfo:eu-repo/semantics/article
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